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Characterization of the open-loop nonlinear response properties of hippocampal dentate granule cells
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Characterization of the open-loop nonlinear response properties of hippocampal dentate granule cells
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Characterization of the open-loop nonlinear response properties of hippocampal dentate granule cells
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Dissertation
Characterization of the open-loop nonlinear response properties of hippocampal dentate granule cells
1991
Overview
The goal of this thesis was to characterize the nonlinear response properties of the perforant path projection from the entorhinal cortex to granule cells in open-loop conditions, i.e., in the absence of all other modulatory influences mediated by interneurons and connections between subsystems. These studies made use of the transverse, in vitro hippocampal slice to investigate open-loop conditions because granule cells can be activated by perforant path stimulation, but multisynaptic feedback connections involving other hippocampal subsystems are eliminated in this preparation. However, many different populations of interneurons reside in the dentate gyrus and the other subsystems of the hippocampus that could influence granule cell nonlinear response properties in a slice preparation. For example, GABAergic neurons are abundant in all layers of the dentate gyrus, and both GABA$\\sb{\\rm A}$ and GABA$\\sb{\\rm B}$ receptors are activated by stimulation of the perforant path in a slice preparation. The influence of GABAergic interneurons was pharmacologically eliminated with the use of the GABA$\\sb{\\rm A}$ antagonist, bicuculline, and the GABA$\\sb{\\rm B}$ antagonist, saclofen. To eliminate non-GABAergic populations of interneurons, a portion of the dentate gyrus was isolated from the slice preparation. The isolation procedure had no effect on granule cell nonlinear response properties, demonstrating that interneurons in the deep hilus, CA1 and CA3 do not influence granule cell input/output properties. Finally, to determine the influence of interneurons with axons that project in the longitudinal axis of the hippocampus, granule cell response properties in 600 $\\mu$m and 300 $\\mu$m slices were compared. Based on these studies, the optimal open-loop conditions for examining the contribution of intrinsic properties of granule cells to their nonlinear response characteristics consists of 300 $\\mu$m slices in the presence of GABA antagonists. (Abstract shortened with permission of author.)
