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Central neural pathway mediating splanchnic osmosensation
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Dissertation
Central neural pathway mediating splanchnic osmosensation
1992
Overview
These studies were designed to determine the central neural pathway which transmits splanchnic osmotic information to vasopressin neurons in the hypothalamus. In order to evaluate the role of strategic brain sites, electrolytic and chemical lesions were induced into these areas one week prior to either gastric infusions of hypertonic saline (598 mOsm/kg; 2ml/4min) or hemorrhage (2.5ml/300g) in conscious rats with indwelling tail artery catheters and naso-gastric tubes. The results determined that the neural signalling of salt intake is mediated by the A1 neurons in the caudal ventrolateral medulla which project through the ventral noradrenergic bundle (VNAB) to the diagonal band of Broca (DB). Noncatecholaminergic neurons within the DB then transmit this input caudally to the AVP cells in the PVN and SON. This central osmotic pathway is mostly segregated from the catecholaminergic projections mediating the AVP response to hemorrhage as far rostral as the pons, and therefore the primary integration site of osmotic and blood volume information may be within the hypothalamus, most likely the diagonal band. The identified pathway may be vital for the proper regulation of AVP secretion as well as the modulation of other autonomic functions which are required for the maintenance of osmotic homeostasis.
Publisher
ProQuest Dissertations & Theses
Subject
ISBN
9798641499178
