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The effects of nicotine and expectancy to smoke on functional and effective brain connectivity: fMRI studies
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Dissertation
The effects of nicotine and expectancy to smoke on functional and effective brain connectivity: fMRI studies
2006
Overview
Recent brain imaging studies have shed light on the effects of nicotine on human cognition. However, few efforts have investigated how changes in brain connectivity may engender nicotine-induced cognitive modulation. Recent studies have also examined the effects of drug cues in addicts; however, little has been established about the influence of perceived drug availability on these responses and the resulting changes in brain connectivity. Using functional magnetic resonance imaging (fMRI), we investigated the effects of nicotine on brain connectivity during a verbal and visual working memory (WM) task. We have shown that nicotine modulates connectivity in a cortico-striatal-thalamic loop during the verbal WM task in which nicotine also improved behavioural performance. In a second inquiry using a cue reactivity paradigm and fMRI, we showed that smoking cue-dependent functional connectivity was significantly greater in subjects that were in a state of expectation to smoke.
Publisher
ProQuest Dissertations & Theses
Subject
ISBN
0494249374, 9780494249376
