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The roles of cyclin-dependent kinase 11 (CDK11) protein kinases during mammalian development
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The roles of cyclin-dependent kinase 11 (CDK11) protein kinases during mammalian development
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The roles of cyclin-dependent kinase 11 (CDK11) protein kinases during mammalian development
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Dissertation
The roles of cyclin-dependent kinase 11 (CDK11) protein kinases during mammalian development
2005
Overview
CDK11 gene encodes two proteins, p110 and p58. CDK11 p110 proteins are part of large-molecular-weight complexes containing RNA polymerase II, transcriptional elongation and general pre-mRNA splicing factors, suggesting they couple transcription and pre-mRNA splicing. CDK11 p58 is expressed only during G2/M from an internal ribosome entry site (IRES) present in the mRNA encoding CDK11p110 and appears to regulate mitosis. To examine the in vivo role of CDK11p110/p58 kinases, we generated CDK11p110/p58-null mice and found CDK11 p110/p58 deficiency results in early embryonic lethality and apoptosis between E3.5 and E4.0. Cells within CDK11p110/p58-/- embryos exhibit both proliferative defects and a mitotic arrest. These results indicated that the CDK11p110/p58 kinases are essential for cellular viability and normal early embryonic development. CDK11p110/p58 T cell-specific knockout mice generated by using Cre/loxP system show defects in T cell development. Deletion of CDK11p110/p58 in thymocytes results in a block at the double negative (DN) stage due to the defective pre-TCR signaling, impaired proliferation and apoptosis. CDK11p110/p58 deficiency in thymocytes also affects alternative splicing of CD45. Taken together, these results indicate that CDK11 protein kinases play important roles in transcription, splicing and mitotic regulation.
