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Electrical activity in murine ventricular myocytes: Simulation studies
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Dissertation
Electrical activity in murine ventricular myocytes: Simulation studies
2002
Overview
Mathematical models were developed to reconstruct the action potentials recorded in murine (rat, mouse) ventricular myocytes. The equations in these models (Hodgkin-Huxley-type) are based on biophysical, experimentally-derived descriptors of ionic currents and antiporters. The simulation results demonstrate that the differential density and reactivation kinetics of the Ca2+ -independent transient outward K+ current (It ), and the transmural gradient in the Na+ channel (I Na) density underlie the intrinsically heterogeneous nature of excitation, repolarization and excitation-contraction (E-C) coupling characteristics in the adult rat ventricle. The longer endocardial action potential duration (APD) results in a net increase of the associated Ca2+ fluxes and the sarcoplasmic reticulum (SR) Ca2+ load. This leads to a higher peak systolic value of the Ca2+ transient ([Ca 2+]i) in the endocardial cells, compared to epicardial ones. Model simulations indicate that the electrophysiological alterations (prolonged APD, abnormal [Ca2+]i) associated with the type-I form of diabetes in rat right ventricular myocytes is the result of concomitant changes in the properties of It, the steady-state outward K+ current (ISS), the L-type Ca2+ current (ICaL), the Na+-K+ pump current (IKslow), and a depressed uptake of Ca2+ ions into the SR. Model analysis also shows that the repolarization differences between rat and mouse cardiac action potentials can be mainly attributed to the presence of the slowly inactivating, delayed rectifier K+ current (IKslow) in mouse, but not in rat. In conclusion, these results provide novel, semi-quantitative insights into the ionic basis of cardiac repolarization and excitation-contraction coupling in murine ventricular myocytes isolated from healthy and diseased hearts.
Publisher
ProQuest Dissertations & Theses
Subject
ISBN
0493696113, 9780493696119
