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A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug bioavailability in Elderly patients

by Sarah mahmoud saleh alsafar , Ahmed Ibrahim Ahmed Hayyan , Alsaedi, Khalid Abdullah M , Alluqmani, Abdulhadi Ayied , Abbas Abdullah Falatah , Hatim Fahad AI Barakati , Samir Ahmad Noor Alkhayyat , Rana Fahad Albarakati , Bader Mesfer Abdullah alasiri , Rami Ayman A. Hariri

in Steroids

2024

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A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug bioavailability in Elderly patients

in Steroids

2024

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Journal Article

A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug bioavailability in Elderly patients

Sarah mahmoud saleh alsafar,

Ahmed Ibrahim Ahmed Hayyan,

Alsaedi, Khalid Abdullah M,

Alluqmani, Abdulhadi Ayied,

Abbas Abdullah Falatah,

Hatim Fahad AI Barakati,

Samir Ahmad Noor Alkhayyat,

Rana Fahad Albarakati,

Bader Mesfer Abdullah alasiri,

Rami Ayman A. Hariri

2024

Overview

Aim: To examine the bioavailability of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in elderly patients and its implications for clinical practice.NSAIDs are widely used for managing chronic pain and inflammation in elderly patients. Age-related physiological changes, including altered gastrointestinal absorption, hepatic metabolism, and renal clearance, significantly affect NSAID bioavailability and therapeutic outcomes. These changes increase the risk of adverse effects, such as gastrointestinal bleeding, renal toxicity, and cardiovascular complications, particularly in the context of polypharmacy and comorbidities. This review highlights the pharmacokinetic and pharmacodynamic variations in elderly patients and emphasizes the need for individualized dosing, regular monitoring, and the use of adjunctive therapies to optimize NSAID safety and efficacy.

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Publisher

Nicholson School of Communication and Media at the University of Central Florida

Subject

Steroids