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Neurophysiological Mechanisms of Memory Consolidation During Sleep Uncovered Through Targeted Memory Reactivation
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Dissertation
Neurophysiological Mechanisms of Memory Consolidation During Sleep Uncovered Through Targeted Memory Reactivation
2025
Overview
Memory consolidation during sleep is thought to depend on the precise temporal coordination of key electrophysiological events, including hippocampal sharp-wave ripples (SWRs), thalamocortical spindles, cortical high-frequency oscillations (CHFOs), and slow oscillations. Despite progress in animal models, the mechanistic interplay between these oscillations and behavioral memory outcomes remains poorly understood in humans. Intracranial EEG (iEEG) offers a unique opportunity to directly observe these dynamics with high spatial and temporal resolution, yet its application in the context of targeted memory reactivation (TMR) during natural sleep has been limited. This study investigated how auditory cues delivered during sleep influence neural signatures of memory consolidation—specifically cue-locked changes in hippocampal ripple activity, thalamo-cortical spindles, and cortical CHFOs—and whether these changes predict post-sleep memory performance. We aimed to identify electrophysiological markers that index a brain state receptive to memory reactivation and stabilization.
Publisher
ProQuest Dissertations & Theses
Subject
ISBN
9798286458899
