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IDDF2025-ABS-0051 Efficacy and safety of the all-in-one device assisted hybrid ESD for large colorectal polyps: a prospective, multicenter, single-arm clinical trial
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IDDF2025-ABS-0051 Efficacy and safety of the all-in-one device assisted hybrid ESD for large colorectal polyps: a prospective, multicenter, single-arm clinical trial
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IDDF2025-ABS-0051 Efficacy and safety of the all-in-one device assisted hybrid ESD for large colorectal polyps: a prospective, multicenter, single-arm clinical trial
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Journal Article
IDDF2025-ABS-0051 Efficacy and safety of the all-in-one device assisted hybrid ESD for large colorectal polyps: a prospective, multicenter, single-arm clinical trial
2025
Overview
BackgroundHybrid endoscopic submucosal dissection (ESD) incorporates snare-assisted resection to reduce technical difficulty and perforation risk in anatomically complex colon lesions. The All In OneTM (AIO) snare probe, which integrates an ESD knife, needle injector, snare, and argon gas spray - facilitates complete lesion removal using a single instrument during hybrid ESD. This study aims to evaluate the efficacy and safety of the AIOTM snare probe for large colorectal polyp during hybrid ESD.MethodsThis prospective single-arm multicenter trial enrolled patients from five clinical centers between November 2021 and November 2022, who presented with sessile, sub-pedunculated, or broad-based polyp measured 1–3 cm in diameter. All patients underwent hybrid ESD assisted by the AIOTM device. The primary outcome was the en bloc resection rate. The secondary outcomes were complete resection rate, hemostasis success rate, device-related adverse events, intraoperative/postoperative bleeding and perforation occurrences.ResultsA total of 161 patients ultimately enrolled in the study, with 173 target polyps removed by AIOTM (IDDF2025-ABS-0051 figure 1). The average polyp diameter was 1.42 ± 0.47 cm (range 1–3 cm). The en bloc resection rate was 94.8% (164/173) (95% CI: 90.4% - 97.6%). The complete resection rate was 95.4% (165/173) (95% CI: 91.1% - 98.0%), and the hemostasis success rate was 94.2% (163/173) (95% CI: 89.6% - 97.2%). Device-related adverse events occurred in 1.2% (2/161) of patients, both cases involving delayed bleeding. No intraoperative perforation or delayed perforation was reported.Abstract IDDF2025-ABS-0051 Figure 1ConclusionsIn this study, we demonstrated that the AIOTM device achieved favorable efficacy and safety during hybrid ESD procedures. Further large-scale studies are needed.
Publisher
BMJ Publishing Group LTD
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