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Evaluating Salivary Lipid Profile in Patients with and without Periodontal Disease – A Cross Sectional Study
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Evaluating Salivary Lipid Profile in Patients with and without Periodontal Disease – A Cross Sectional Study
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Journal Article
Evaluating Salivary Lipid Profile in Patients with and without Periodontal Disease – A Cross Sectional Study
2025
Overview
Introduction: Periodontitis is an inflammatory condition triggered by an imbalance in the periodontal bacterial community, leading to damage of the tooth-supporting structures. Over recent decades, numerous studies have highlighted a significant link between periodontitis and coronary heart disease. Lipids gets adhered in the intima layer, where it is oxidized, and leads to the beginning of coronary heart disease. Saliva, being an ultrafiltrate of plasma, serves as a valuable non-invasive medium for diagnostic purposes. The present study aimed to assess salivary lipid profile parameters such as Triglycerides (TGL), High-Density Lipoproteins (HDL), Low-Density Lipoproteins (LDL), Very Low-Density Lipoproteins (VLDL), and Total Cholesterol in individuals with and without periodontal disease. Methods: This study included 30 subjects. Unstimulated salivary samples were collected into sterile containers from 15 patients with chronic periodontitis and 15 individuals with healthy periodontium. Lipid profile levels were estimated using calorimetric method. Results: Patients with periodontal disease exhibited increased salivary levels of LDL, Total Cholesterol and decreased HDL levels by supporting the hypothesis that salivary lipid levels will be increased in patients with chronic periodontitis which may act as a precursor for atherosclerosis. Conclusion: Patients with chronic periodontitis have increased LDL and total cholesterol levels in saliva which could be a risk factor for developing atherosclerosis.
Publisher
Journal of Advanced Medical and Dental Sciences Research (JAMDSR)
Subject
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