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Function and Integrity of the Blood-Brain Barrier: Implications for Vector-Borne Diseases
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Function and Integrity of the Blood-Brain Barrier: Implications for Vector-Borne Diseases
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Dissertation
Function and Integrity of the Blood-Brain Barrier: Implications for Vector-Borne Diseases
2026
Overview
The blood-brain barrier is essential to regulating the influx and efflux of biological substances between the blood and the brain. BBB is a highly selective and permeable structure composed of a basement membrane, endothelial cells, pericytes, and astrocyte end feet, protecting the brain from unwanted toxins and molecules while allowing essential nutrients to pass. Vector-borne diseases commonly spread to the central nervous system, presenting an array of neurological consequences. This study explores the mechanisms of how various pathogens cross the BBB and infect the CNS. This study analyzes cellular and molecular components of BBB which facilitate the dissemination of disease-causing pathogens. Here we looked at whether neurological conditions arising from vector-borne disease are due to induced or existing permeability of the BBB, or if a pathogen is able to cross an intact BBB. We hope to provide valuable insights informing the development of potential therapeutics capable of mitigation of infection sequelae or preventing the development of neurological conditions.
Publisher
ProQuest Dissertations & Theses
Subject
ISBN
9798197897343
