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CSF-Tau and CSF-Abeta1-42 in Posterior Cortical Atrophy
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Journal Article
CSF-Tau and CSF-Abeta1-42 in Posterior Cortical Atrophy
2010
Overview
Objective: Our purpose was to measure Aβ1-42, T-tau and P-tau181 in the cerebrospinal fluid (CSF) of patients with posterior cortical atrophy (PCA), a presenile dementia likely to represent a variant of Alzheimer's disease (AD). Methods: CSF samples from 34 subjects including 9 patients with PCA, 11 age-matched patients with AD and 14 age-matched cognitively healthy controls were analyzed using commercially available ELISA kits. Results: The Aβ1-42, T-tau and P-tau181 levels in PCA patients differed significantly (p < 0.02) from those in healthy controls but were indistinguishable from subjects with a clinical diagnosis of AD. Conclusion: High T-tau and P-tau181 and low Aβ1-42 levels in PCA - typically observed in AD - indicate that the underlying pathology of PCA is usually AD. If these findings are replicated in PCA patients with autopsy-confirmed AD neuropathology, PCA patients may be eligible for disease-modifying AD treatments. Copyright © 2010 S. Karger AG, Basel [PUBLICATION ABSTRACT]
Publisher
S. Karger AG
Subject
