Asset Details
Do you wish to reserve the book?
The effect of antecedent hypoglycaemia on beta^sub 2^-adrenergic sensitivity in healthy participants with the Arg16Gly polymorphism of the beta^sub 2^-adrenergic receptor
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The effect of antecedent hypoglycaemia on beta^sub 2^-adrenergic sensitivity in healthy participants with the Arg16Gly polymorphism of the beta^sub 2^-adrenergic receptor
Do you wish to request the book?
The effect of antecedent hypoglycaemia on beta^sub 2^-adrenergic sensitivity in healthy participants with the Arg16Gly polymorphism of the beta^sub 2^-adrenergic receptor
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The effect of antecedent hypoglycaemia on beta^sub 2^-adrenergic sensitivity in healthy participants with the Arg16Gly polymorphism of the beta^sub 2^-adrenergic receptor
2011
Overview
Homozygosity for glycine at codon 16 (GlyGly) of the β^sub 2^-adrenergic receptor may alter receptor sensitivity upon chronic stimulation and has been implicated in the pathogenesis of hypoglycaemia unawareness. We compared the effect of antecedent hypoglycaemia on β^sub 2^-adrenergic receptor sensitivity between GlyGly participants and those with arginine 16 homozygosity (ArgArg) for the β^sub 2^-adrenergic receptor. We enrolled 16 healthy participants, who were either GlyGly (n=8) or ArgArg (n=8). They participated randomly in two 2 day experiments. Day 1 consisted of two 2-h hyperinsulinaemic hypoglycaemic (2.8 mmol/l) or euglycaemic (4.8 mmol/l) glucose clamps. On day 2, we measured the forearm vasodilator response to the β^sub 2^-adrenergic receptor agonist salbutamol and the dose of isoprenaline required to increase the heart rate by 25 bpm (IC^sup 25^). The vasodilator response to salbutamol tended to be greater after antecedent hypoglycaemia than after euglycaemia (p=0.078), consistent with increased β^sub 2^-adrenergic receptor sensitivity. This effect was driven by a significant increase in β^sub 2^-adrenergic receptor sensitivity following hypoglycaemia compared with euglycaemia in ArgArg participants (p=0.019), whereas no such effect was observed in the GlyGly participants. Antecedent hypoglycaemia tended to decrease the IC^sup 25^ in ArgArg participants, whereas the reverse occurred in the GlyGly participants (GlyGly vs ArgArg group p=0.047). Antecedent hypoglycaemia did not affect β^sub 2^-adrenergic receptor sensitivity in healthy GlyGly participants, but increased it in ArgArg participants. If these results also hold for participants with type 1 diabetes, such an increase in β^sub 2^-adrenergic receptor sensitivity may potentially reduce the risk of repeated hypoglycaemia and the subsequent development of hypoglycaemia unawareness in ArgArg diabetic participants. ClinicalTrials.gov NCT00160056 Radboud University Nijmegen Medical Centre.[PUBLICATION ABSTRACT]
Publisher
Springer Nature B.V
Subject
