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Macular pigment, its measurement in clinics and its link with macular disease
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Macular pigment, its measurement in clinics and its link with macular disease
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Dissertation
Macular pigment, its measurement in clinics and its link with macular disease
2010
Overview
The study presented here had two main objectives: 1) to evaluate and test under clinical conditions a new device (MPS 9000) designed for Macular Pigment Optical Density (MPOD) measurements and 2) to investigate whether MP enhancement due to lutein supplementation has any functional benefits in early stage AMD. The MPS 9000 measures MPOD based on the principles of Heterochromatic Flicker Photometry (HFP). The device was calibrated, tested for repeatability and evaluated against an optical technique for measuring MPOD, the Macular Pigment Reflectometer (MPR). The validity of a novel feature the MPS 9000 incorporates, that makes feasible the estimation of MPOD based on the age of the observer, was investigated. The outcomes of three pilot studies designed for testing the performance of the MPS 9000 under clinical conditions are reported. They investigate the relation of MPOD to ethnicity, MPOD distribution in a large data set (5616 eyes) and MPOD differences between ARM patients and age-matched normals. In chapter five are presented MPOD spatial profiles collected with the MPS 9000 and the MPR. This study provides insight into the systematic differences widely described in the literature between optical based and flicker based techniques for estimating MPOD. A 12 month double-blind placebo-controlled lutein supplementation clinical trial was conducted in the University of Manchester and the University of Maastricht. The thirty seven ARM patients recruited in Manchester were asked to take either lutein supplements or placebo capsules for the period of 12 months. During the time course of the study, their Visual Acuity (VA), Contrast Sensitivity (CS) and Dark Adaptation (DA) were measured. MPOD levels were recorded with the MPS 9000. The outcomes of the Lutein Supplementation study suggest a positive effect of lutein on MPOD levels and the kinetics of DA of the participants taking lutein. No statistically significant effect was found for the CS and the VA.
Publisher
ProQuest Dissertations & Theses
Subject
