Asset Details
Do you wish to reserve the book?
Regulation of meiotic chromosome interactions in Caenorhabditis elegans
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Regulation of meiotic chromosome interactions in Caenorhabditis elegans
Do you wish to request the book?
Regulation of meiotic chromosome interactions in Caenorhabditis elegans
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Dissertation
Regulation of meiotic chromosome interactions in Caenorhabditis elegans
2011
Overview
Faithful segregation of homologous chromosomes during meiosis requires pairing, synapsis, and crossing-over. In the nematode Caenorhabditis elegans, homolog pairing and synapsis depend on pairing centers, special regions near one end of each chromosome that interact with the nuclear envelope and cytoplasmic microtubules. Pairing centers are required for nuclear reorganization at the onset of meiosis. Here, I show that pairing centers recruit the Polo-like kinase PLK-2 to induce nuclear envelope remodeling, chromosome pairing, and synapsis. Recruitment of PLK-2 is also required to mediate a cell cycle delay and selective apoptosis of nuclei containing unsynapsed chromosomes, establishing a molecular link between these two quality control mechanisms. I also show that the checkpoint kinase CHK-2 is recruited to the interface of pairing centers and nuclear envelope proteins, consistent with its role in promoting homolog interactions and nuclear reorganization. Interestingly, PLK-2 is later recruited to the axes of paired and synapsed chromosomes where it plays a downstream role in synaptonemal complex dynamics. This work reveals new functions for the conserved family of Polo-like kinases, and advances our understanding of how meiotic processes are properly coordinated to ensure transmission of genetic information from parents to progeny.
