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Dose considerations in the SO sub(2)-exposed exercising asthmatic
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Dose considerations in the SO sub(2)-exposed exercising asthmatic
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Journal Article
Dose considerations in the SO sub(2)-exposed exercising asthmatic
1983
Overview
In this study the authors have demonstrated that by combining data from several recent controlled human exposure studies it is possible systematically to relate increases in airways resistance to the rate of SO sub(2) exposure (D sub(min)) in the exercising asthmatic. It was determined that the mode of SO sub(2) exposure (oral vs. oronasal) greatly influences the degree of response in the asthmatic. Using both the linear and exponential model, the authors have constructed a matrix which allows direct estimation of the combined minute ventilaton ( super(.)V) sub(E)) and SO sub(2) concentration (as ppm or mu g/L) required to achieve various levels of specific airways resistance increase.
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