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Therapeutic opportunities for manipulating T sub(Reg) cells in autoimmunity and cancer
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Therapeutic opportunities for manipulating T sub(Reg) cells in autoimmunity and cancer
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Journal Article
Therapeutic opportunities for manipulating T sub(Reg) cells in autoimmunity and cancer
2012
Overview
Forkhead box P3 (FOXP3)-expressing regulatory T (T sub(Reg)) cells have a pivotal role in the regulation of immune responses and in the maintenance of immunological self-tolerance. These cells have emerged as attractive targets for strategies that allow the steering of immune responses in desired directions - arming the immune system to destroy infected cells and cancer cells or downregulating it to limit tissue destruction in autoimmunity. Efforts to understand the generation, activation and function of T sub(Reg) cells should permit the development of therapeutics for reprogramming the immune system. In this Review, we discuss insights into the generation of T sub(Reg) cells, their involvement in disease and the molecular basis of the dominant tolerance exerted by FOXP3 super(+) T sub(Reg) cells that could permit their safe and specific manipulation in humans.
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