MbrlCatalogueTitleDetail

Do you wish to reserve the book?
Defective sphingosine 1-phosphate receptor 1 (S1P sub(1)) phosphorylation exacerbates T sub(H)17-mediated autoimmune neuroinflammation
Defective sphingosine 1-phosphate receptor 1 (S1P sub(1)) phosphorylation exacerbates T sub(H)17-mediated autoimmune neuroinflammation
by Wu, Linfeng , Huang, Yingxiang , Ho, Peggy P , Axtell, Robert C , Steinman, Lawrence , Han, David K , Moon, Byoung San , Hla, Timothy , Steinberg, Gary K , Snyder, Michael P , Han, May H , Arac, Ahmet , Blaho, Victoria A , Lewis, David B , Sobel, Raymond A , Garris, Christopher S , Acharya, Swati
in Autoimmunity
2013
Yes Please
Hey, we have placed the reservation for you!
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
You are currently in the queue to collect this book. You will be notified once it is your turn to collect the book.
Done
Oops! Something went wrong.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Done
Are you sure you want to remove the book from the shelf?
Defective sphingosine 1-phosphate receptor 1 (S1P sub(1)) phosphorylation exacerbates T sub(H)17-mediated autoimmune neuroinflammation
by Wu, Linfeng , Huang, Yingxiang , Ho, Peggy P , Axtell, Robert C , Steinman, Lawrence , Han, David K , Moon, Byoung San , Hla, Timothy , Steinberg, Gary K , Snyder, Michael P , Han, May H , Arac, Ahmet , Blaho, Victoria A , Lewis, David B , Sobel, Raymond A , Garris, Christopher S , Acharya, Swati
in Autoimmunity
2013
Confirm
Oops! Something went wrong.
Oops! Something went wrong.
While trying to remove the title from your shelf something went wrong :( Kindly try again later!
Done
Title added to your shelf!
Title added to your shelf!
View what I already have on My Shelf.
Thanks
Oops! Something went wrong.
Oops! Something went wrong.
While trying to add the title to your shelf something went wrong :( Kindly try again later!
Done
Do you wish to request the book?
Defective sphingosine 1-phosphate receptor 1 (S1P sub(1)) phosphorylation exacerbates T sub(H)17-mediated autoimmune neuroinflammation
Defective sphingosine 1-phosphate receptor 1 (S1P sub(1)) phosphorylation exacerbates T sub(H)17-mediated autoimmune neuroinflammation
by Wu, Linfeng , Huang, Yingxiang , Ho, Peggy P , Axtell, Robert C , Steinman, Lawrence , Han, David K , Moon, Byoung San , Hla, Timothy , Steinberg, Gary K , Snyder, Michael P , Han, May H , Arac, Ahmet , Blaho, Victoria A , Lewis, David B , Sobel, Raymond A , Garris, Christopher S , Acharya, Swati
in Autoimmunity
2013

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
How would you like to get it?
We have requested the book for you! Sorry the robot delivery is not available at the moment
Submit
We have requested the book for you!
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Done
Oops! Something went wrong.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Done
Mohammed Bin Rashid Library /
Catalogue /
Defective sphingosine 1-phosphate receptor 1 (S1P sub(1)) phosphorylation exacerbates T sub(H)17-mediated autoimmune neuroinflammation
Defective sphingosine 1-phosphate receptor 1 (S1P sub(1)) phosphorylation exacerbates T sub(H)17-mediated autoimmune neuroinflammation
Journal Article

Defective sphingosine 1-phosphate receptor 1 (S1P sub(1)) phosphorylation exacerbates T sub(H)17-mediated autoimmune neuroinflammation

Wu, Linfeng,
Huang, Yingxiang,
Ho, Peggy P,
Axtell, Robert C,
Steinman, Lawrence,
Han, David K,
Moon, Byoung San,
Hla, Timothy,
Steinberg, Gary K,
Snyder, Michael P,
Han, May H,
Arac, Ahmet,
Blaho, Victoria A,
Lewis, David B,
Sobel, Raymond A,
Garris, Christopher S,
Acharya, Swati
2013
Request Book From Autostore and Choose the Collection Method
Overview
Sphingosine 1-phosphate (S1P) signaling regulates lymphocyte egress from lymphoid organs into systemic circulation. The sphingosine phosphate receptor 1 (S1P sub(1)) agonist FTY-720 (Gilenya) arrests immune trafficking and prevents multiple sclerosis (MS) relapses. However, alternative mechanisms of S1P-S1P sub(1) signaling have been reported. Phosphoproteomic analysis of MS brain lesions revealed S1P sub(1) phosphorylation on S351, a residue crucial for receptor internalization. Mutant mice harboring an S1pr1 gene encoding phosphorylation-deficient receptors (S1P sub(1)(S5A)) developed severe experimental autoimmune encephalomyelitis (EAE) due to autoimmunity mediated by interleukin 17 (IL-17)-producing helper T cells (T sub(H)17 cells) in the peripheral immune and nervous system. S1P sub(1) directly activated the Jak-STAT3 signal-transduction pathway via IL-6. Impaired S1P sub(1) phosphorylation enhances T sub(H)17 polarization and exacerbates autoimmune neuroinflammation. These mechanisms may be pathogenic in MS.
Share this book
Add to My Shelf
Subject

Autoimmunity

MBRLCatalogueRelatedBooks

Related Items

Related Items

We currently cannot retrieve any items related to this title. Kindly check back at a later time.