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OAT3-mediated extrusion of the super(99m)Tc-ECD metabolite in the mouse brain
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OAT3-mediated extrusion of the super(99m)Tc-ECD metabolite in the mouse brain
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OAT3-mediated extrusion of the super(99m)Tc-ECD metabolite in the mouse brain
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Journal Article
OAT3-mediated extrusion of the super(99m)Tc-ECD metabolite in the mouse brain
2014
Overview
After administration of the super(99m)Tc complex with N,N'-1,2-ethylenediylbis-L-cysteine diethyl ester ( super(99m)Tc-ECD), a brain perfusion imaging agent, the radioactive metabolite is trapped in primate brain, but not in mouse and rat. Here, we investigate the involvement of metabolite extrusion by organic anion transporter 3 (OAT3), which is highly expressed at the blood-brain barrier in mice, in this species difference. The efflux rate of radioactivity in the cerebrum of Oat3 super(-/-) mice at later phase was 20% of that of control mice. Thus, organic anion transporters in mouse brain would be involved in the low brain retention of radioactivity after super(99m)Tc-ECD administration.
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