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Activation of early events of the mitogenic response by a P sub(2Y) purinoceptor with covalently bound 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate
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Activation of early events of the mitogenic response by a P sub(2Y) purinoceptor with covalently bound 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate
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Activation of early events of the mitogenic response by a P sub(2Y) purinoceptor with covalently bound 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate
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Journal Article
Activation of early events of the mitogenic response by a P sub(2Y) purinoceptor with covalently bound 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate
1990
Overview
3'-O-(4-Benzoyl)benzoyl-ATP (BzATP), a photoaffinity analog of ATP, was used as a ligand for a P sub(2Y) purinoceptor (adenine nucleotide receptor) present in intact Swiss 3T3 and 3T6 cells and A-431 epidermoid carcinoma cells. Photoincorporated BzATP also stimulated the production of prostaglandin E sub(2) and the accumulation of cyclic AMP. In previous studies, we demonstrated that these three events are obligatory early steps in a pathway leading to DNA synthesis in the above cell lines. The results indicate that BzATP is an effective agonist for the P sub(2Y) purinoceptor concerned with stimulation of DNA synthesis in 3T3, 3T6, and A-431 cells. Furthermore, after photolysis it becomes irreversibly associated with intact cells and promotes the activation of early events required for DNA synthesis.
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