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Increased skeletal muscle glucose uptake by rosemary extract through AMPK activation
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Increased skeletal muscle glucose uptake by rosemary extract through AMPK activation
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Journal Article
Increased skeletal muscle glucose uptake by rosemary extract through AMPK activation
2015
Overview
Stimulation of the energy sensor AMP-activated Kinase (AMPK) has been viewed as a targeted approach to increase glucose uptake by skeletal muscle and control blood glucose homeostasis. Rosemary extract (RE) has been reported to activate AMPK in hepatocytes and reduce blood glucose levels in vivo but its effects on skeletal muscle are not known. In the present study, we examined the effects of RE and the mechanism of regulation of glucose uptake in muscle cells. RE stimulated glucose uptake in L6 myotubes in a dose- and time-dependent manner. Maximum stimulation was seen with 5 ug/mL of RE for 4 h (184% +/= 5.07% of control, p
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