Asset Details
Do you wish to reserve the book?
A riboswitch selective for the queuosine precursor preQ sub(1) contains an unusually small aptamer domain
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
A riboswitch selective for the queuosine precursor preQ sub(1) contains an unusually small aptamer domain
Do you wish to request the book?
A riboswitch selective for the queuosine precursor preQ sub(1) contains an unusually small aptamer domain
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
A riboswitch selective for the queuosine precursor preQ sub(1) contains an unusually small aptamer domain
2007
Overview
A previous bioinformatics-based search for riboswitches yielded several candidate motifs in eubacteria. One of these motifs commonly resides in the 5' untranslated regions of genes involved in the biosynthesis of queuosine (Q), a hypermodified nucleoside occupying the anticodon wobble position of certain transfer RNAs. Here we show that this structured RNA is part of a riboswitch selective for 7-aminomethyl-7-deazaguanine (preQ sub(1)), an intermediate in queuosine biosynthesis. Compared with other natural metabolite-binding RNAs, the preQ sub(1) aptamer appears to have a simple structure, consisting of a single stem-loop and a short tail sequence that together are formed from as few as 34 nucleotides. Despite its small size, this aptamer is highly selective for its cognate ligand in vitro and has an affinity for preQ sub(1) in the low nanomolar range. Relatively compact RNA structures can therefore serve effectively as metabolite receptors to regulate gene expression.
Subject
We currently cannot retrieve any items related to this title. Kindly check back at a later time.