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Frugal and Translatable 15OO2 Production for Human Inhalation with Direct Delivery from the Cyclotron to a Hybrid PET/MR
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Frugal and Translatable 15OO2 Production for Human Inhalation with Direct Delivery from the Cyclotron to a Hybrid PET/MR
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Frugal and Translatable 15OO2 Production for Human Inhalation with Direct Delivery from the Cyclotron to a Hybrid PET/MR
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Journal Article
Frugal and Translatable 15OO2 Production for Human Inhalation with Direct Delivery from the Cyclotron to a Hybrid PET/MR
2024
Overview
Oxygen-15 (β+, t1/2 = 122 s) radiolabeled diatomic oxygen, in conjunction with positron emission tomography, is the gold standard to quantitatively measure the metabolic rate of oxygen consumption in the living human brain. We present herein a protocol for safe and effective delivery of [15O]O2 over 200 m to a human subject for inhalation. A frugal quality control testing procedure was devised and validated. This protocol can act as a blueprint for other sites seeking to implement similar imaging programs.Oxygen-15 (β+, t1/2 = 122 s) radiolabeled diatomic oxygen, in conjunction with positron emission tomography, is the gold standard to quantitatively measure the metabolic rate of oxygen consumption in the living human brain. We present herein a protocol for safe and effective delivery of [15O]O2 over 200 m to a human subject for inhalation. A frugal quality control testing procedure was devised and validated. This protocol can act as a blueprint for other sites seeking to implement similar imaging programs.
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