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The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a b-catenin-dependent pathway
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The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a b-catenin-dependent pathway
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The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a b-catenin-dependent pathway
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Journal Article
The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a b-catenin-dependent pathway
2010
Overview
Intracellular nucleic acid sensors detect microbial RNA and DNA and trigger the production of type I interferon. However, the cytosolic nucleic acid-sensing system remains to be fully identified. Here we show that the cytosolic nucleic acid-binding protein LRRFIP1 contributed to the production of interferon-b (IFN-b) induced by vesicular stomatitis virus (VSV) and Listeria monocytogenes in macrophages. LRRFIP1 bound exogenous nucleic acids and increased the expression of IFN-b induced by both double-stranded RNA and double-stranded DNA. LRRFIP1 interacted with b-catenin and promoted the activation of b-catenin, which increased IFN-b expression by binding to the C-terminal domain of the transcription factor IRF3 and recruiting the acetyltransferase p300 to the IFN-b enhanceosome via IRF3. Therefore, LRRFIP1 and its downstream partner b-catenin constitute another coactivator pathway for IRF3-mediated production of type I interferon.
