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COMT Valsuper108/158Met polymorphism effects on emotional brain function and negativity bias
by
Schofield, Peter R
, Grieve, Stuart M
, Williams, Leanne M
, Paul, Robert H
, Gatt, Justine M
, Dobson-Stone, Carol
, Gordon, Evian
in
Amygdala
2010
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COMT Valsuper108/158Met polymorphism effects on emotional brain function and negativity bias
by
Schofield, Peter R
, Grieve, Stuart M
, Williams, Leanne M
, Paul, Robert H
, Gatt, Justine M
, Dobson-Stone, Carol
, Gordon, Evian
in
Amygdala
2010
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COMT Valsuper108/158Met polymorphism effects on emotional brain function and negativity bias
Journal Article
COMT Valsuper108/158Met polymorphism effects on emotional brain function and negativity bias
2010
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Overview
Biases toward processing negative versus positive information vary as a function of level of awareness, and are modulated by monoamines. Excessive biases are associated with individual differences in mood and emotional stability, and emotional disorder. Here, we examined the impact of the catechol-O-methyltransferase (COMT) Val[super]108/158Met polymorphism, involved in dopamine and norepinephrine catabolism, on both emotional brain function and self-reported negativity bias. COMT genotyping and self-reported level of negativity bias were completed for 46 healthy participants taking part in the Brain Resource International Database. Functional MRI was undertaken during perception of facial expressions of fear and happiness presented under unmasked (consciously identified) and masked (to prevent conscious detection) conditions. Structural MR images were also acquired. A greater number of COMT Met alleles predicted increased activation in brainstem, amygdala, basal ganglia and medial prefrontal regions for conscious fear, but decreased activation for conscious happiness. This pattern was also apparent for brainstem activation for the masked condition. Effects were most apparent for females. These differences could not be explained by gray matter variations. The Met-related profile of activation, particularly prefrontally, predicted greater negativity bias associated with risk for emotional disorder. The findings suggest that the COMT Met allele modulates neural substrates of negative versus positive emotion processing. This effect may contribute to negativity biases, which confer susceptibility for emotional disorders.
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