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Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS
Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS
by Bodine, Christopher L , Roberts Ii, L Jackson , Matafonova, Elena , Davies, Sean S , Oates, John A , Tirona, Rommel G , Zagol-Ikapitte, Irene , Boutaud, Olivier , Amarnath, Venkataraman
2010
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Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS
by Bodine, Christopher L , Roberts Ii, L Jackson , Matafonova, Elena , Davies, Sean S , Oates, John A , Tirona, Rommel G , Zagol-Ikapitte, Irene , Boutaud, Olivier , Amarnath, Venkataraman
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2010
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Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS
Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS
by Bodine, Christopher L , Roberts Ii, L Jackson , Matafonova, Elena , Davies, Sean S , Oates, John A , Tirona, Rommel G , Zagol-Ikapitte, Irene , Boutaud, Olivier , Amarnath, Venkataraman
2010

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Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS
Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS
Journal Article

Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS

Bodine, Christopher L,
Roberts Ii, L Jackson,
Matafonova, Elena,
Davies, Sean S,
Oates, John A,
Tirona, Rommel G,
Zagol-Ikapitte, Irene,
Boutaud, Olivier,
Amarnath, Venkataraman
2010
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Overview
Levels of reactive γ-ketoaldehydes derived from arachidonate increase in diseases associated with inflammation and oxidative injury. To assess the biological importance of these γ-ketoaldehydes, we previously identified salicylamine as an effective γ-ketoaldehyde scavenger in vitro and in cells. To determine if salicylamine could be administered in vivo, we developed an LC/MS/MS assay to measure salicylamine in plasma and tissues. In mice, half-life (t ) was 62 minutes. Drinking water supplementation (1-10 g/L) generated tissue concentrations (10-500 μM) within the range previously shown to inhibit γ-ketoaldehydes in cells. Therefore, oral administration of salicylamine can be used to assess the contribution of γ-ketoaldehydes in animal models of disease.
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