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Atomic structures of respiratory complex III 2 , complex IV, and supercomplex III 2 -IV from vascular plants
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Atomic structures of respiratory complex III 2 , complex IV, and supercomplex III 2 -IV from vascular plants
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Journal Article
Atomic structures of respiratory complex III 2 , complex IV, and supercomplex III 2 -IV from vascular plants
2021
Overview
Mitochondrial complex III (CIII
) and complex IV (CIV), which can associate into a higher-order supercomplex (SC III
+IV), play key roles in respiration. However, structures of these plant complexes remain unknown. We present atomic models of CIII
, CIV, and SC III
+IV from
determined by single-particle cryoEM. The structures reveal plant-specific differences in the MPP domain of CIII
and define the subunit composition of CIV. Conformational heterogeneity analysis of CIII
revealed long-range, coordinated movements across the complex, as well as the motion of CIII
's iron-sulfur head domain. The CIV structure suggests that, in plants, proton translocation does not occur via the H channel. The supercomplex interface differs significantly from that in yeast and bacteria in its interacting subunits, angle of approach and limited interactions in the mitochondrial matrix. These structures challenge long-standing assumptions about the plant complexes and generate new mechanistic hypotheses.
