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Variants near TERC are associated with mean telomere length
Variants near TERC are associated with mean telomere length
by van der Harst, Pim , Valdes, Ana M , Tobin, Martin D , Ouwehand, Willem , Nelson, Chris , Leach, Irene Mateo , Thompson, John R , van Gilst, Wiek H. , Codd, Veryan , Zhai, Guangju , van Veldhuisen, Dirk J. , Spector, Tim , Kaiser, Michael , Blackburn, Hannah , Samani, Nilesh J , Rafelt, Suzanne , de Boer, Rudolf A , Hall, Alistair S , Navis, Gerjan , Goodall, Alison H , Braund, Peter S , Beveridge, Alan J , Moore, Jasbir , Burton, Paul R , Soranzo, Nicole , Mangino, Massimo
2010
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Variants near TERC are associated with mean telomere length
by van der Harst, Pim , Valdes, Ana M , Tobin, Martin D , Ouwehand, Willem , Nelson, Chris , Leach, Irene Mateo , Thompson, John R , van Gilst, Wiek H. , Codd, Veryan , Zhai, Guangju , van Veldhuisen, Dirk J. , Spector, Tim , Kaiser, Michael , Blackburn, Hannah , Samani, Nilesh J , Rafelt, Suzanne , de Boer, Rudolf A , Hall, Alistair S , Navis, Gerjan , Goodall, Alison H , Braund, Peter S , Beveridge, Alan J , Moore, Jasbir , Burton, Paul R , Soranzo, Nicole , Mangino, Massimo
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2010
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Variants near TERC are associated with mean telomere length
Variants near TERC are associated with mean telomere length
by van der Harst, Pim , Valdes, Ana M , Tobin, Martin D , Ouwehand, Willem , Nelson, Chris , Leach, Irene Mateo , Thompson, John R , van Gilst, Wiek H. , Codd, Veryan , Zhai, Guangju , van Veldhuisen, Dirk J. , Spector, Tim , Kaiser, Michael , Blackburn, Hannah , Samani, Nilesh J , Rafelt, Suzanne , de Boer, Rudolf A , Hall, Alistair S , Navis, Gerjan , Goodall, Alison H , Braund, Peter S , Beveridge, Alan J , Moore, Jasbir , Burton, Paul R , Soranzo, Nicole , Mangino, Massimo
2010

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Variants near TERC are associated with mean telomere length
Variants near TERC are associated with mean telomere length
Journal Article

Variants near TERC are associated with mean telomere length

van der Harst, Pim,
Valdes, Ana M,
Tobin, Martin D,
Ouwehand, Willem,
Nelson, Chris,
Leach, Irene Mateo,
Thompson, John R,
van Gilst, Wiek H.,
Codd, Veryan,
Zhai, Guangju,
van Veldhuisen, Dirk J.,
Spector, Tim,
Kaiser, Michael,
Blackburn, Hannah,
Samani, Nilesh J,
Rafelt, Suzanne,
de Boer, Rudolf A,
Hall, Alistair S,
Navis, Gerjan,
Goodall, Alison H,
Braund, Peter S,
Beveridge, Alan J,
Moore, Jasbir,
Burton, Paul R,
Soranzo, Nicole,
Mangino, Massimo
2010
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Overview
We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 subjects and follow-up replication analyses in 9,492 and identified a locus on 3q26 encompassing the telomerase RNA component TERC, with compelling evidence for association (rs12696304, combined P value 3.72×10−14). Each copy of the minor allele of rs12696304 was associated with ≈75 base pairs shorter mean telomere length equivalent to ≈3.6 years of age-related attrition of mean telomere length.
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