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LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4
LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4
by Panzeri, Ilaria , Bonnal, Raoul JP , Gruarin, Paola , De Francesco, Raffaele , Arrigoni, Alberto , Abrignani, Sergio , Ranzani, Valeria , Bodega, Beatrice , Curti, Serena , Marconi, Maurizio , Geginat, Jens , Pagani, Massimiliano , Rossetti, Grazisa , Provasi, Elena , Sugliano, Elisa
2015
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LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4
by Panzeri, Ilaria , Bonnal, Raoul JP , Gruarin, Paola , De Francesco, Raffaele , Arrigoni, Alberto , Abrignani, Sergio , Ranzani, Valeria , Bodega, Beatrice , Curti, Serena , Marconi, Maurizio , Geginat, Jens , Pagani, Massimiliano , Rossetti, Grazisa , Provasi, Elena , Sugliano, Elisa
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2015
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LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4
LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4
by Panzeri, Ilaria , Bonnal, Raoul JP , Gruarin, Paola , De Francesco, Raffaele , Arrigoni, Alberto , Abrignani, Sergio , Ranzani, Valeria , Bodega, Beatrice , Curti, Serena , Marconi, Maurizio , Geginat, Jens , Pagani, Massimiliano , Rossetti, Grazisa , Provasi, Elena , Sugliano, Elisa
2015

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LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4
LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4
Journal Article

LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4

Panzeri, Ilaria,
Bonnal, Raoul JP,
Gruarin, Paola,
De Francesco, Raffaele,
Arrigoni, Alberto,
Abrignani, Sergio,
Ranzani, Valeria,
Bodega, Beatrice,
Curti, Serena,
Marconi, Maurizio,
Geginat, Jens,
Pagani, Massimiliano,
Rossetti, Grazisa,
Provasi, Elena,
Sugliano, Elisa
2015
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Overview
Long non-coding-RNAs are emerging as important regulators of cellular functions but little is known on their role in human immune system. Here we investigated long intergenic non-coding-RNAs (lincRNAs) in thirteen T and B lymphocyte subsets by RNA-seq analysis and de novo transcriptome reconstruction. Over five hundred new lincRNAs were identified and lincRNAs signatures were described. Expression of linc-MAF-4, a chromatin-associated TH1-specific lincRNA, was inversely correlated with MAF, a TH2-associated transcription factor. Linc-MAF-4 down-regulation skewed T cell differentiation toward TH2. We identified a long-distance interaction between linc-MAF-4 and MAF genomic regions, where linc-MAF-4 associates with LSD1 and EZH2, suggesting linc-MAF-4 regulated MAF transcription by recruitment of chromatin modifiers. Our results demonstrate a key role of lincRNAs in T lymphocyte differentiation.
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