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Incidence of neurodegenerative and cerebrovascular diseases associated with anti-hypertensive drug classes: a study of 34 million patients
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Incidence of neurodegenerative and cerebrovascular diseases associated with anti-hypertensive drug classes: a study of 34 million patients
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Journal Article
Incidence of neurodegenerative and cerebrovascular diseases associated with anti-hypertensive drug classes: a study of 34 million patients
2021
Overview
Antihypertensive drugs (AHTs) are associated with lowered risks of neurodegenerative diseases and stroke. However, the relative risks associated with different AHT classes are unclear. Using an electronic health records network, we compared rates of these disorders over a 2 year period in propensity score matched cohorts of people taking calcium channel blockers (CCBs) compared to those taking other AHT classes. CCBs were associated with a higher incidence of all disorders compared to renin-angiotensin system agents, and a higher incidence of dementia and cerebrovascular disease compared to diuretics. CCBs were associated with a lower incidence of movement disorders and cerebrovascular disease than with β-blockers. The data show that AHT classes confer differential risks of neurodegenerative and cerebrovascular diagnoses.
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