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穴位贴敷治疗功能性消化不良的疗效及对相关脑肠肽的影响
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穴位贴敷治疗功能性消化不良的疗效及对相关脑肠肽的影响
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Journal Article
穴位贴敷治疗功能性消化不良的疗效及对相关脑肠肽的影响
2021
Overview
R245.9; 目的:观察健脾通经止痛膏穴位贴敷治疗肝郁脾虚型功能性消化不良的临床疗效及对血清中5-羟色胺(5-HT)和胃促生长素(Ghrelin)含量的影响.方法:将100例肝郁脾虚型功能性消化不良患者按随机数字表法分为治疗组和对照组,每组50例.治疗组予健脾通经止痛膏穴位贴敷治疗,对照组予枸橼酸莫沙必利片口服治疗.4周为1个疗程,1个疗程后比较两组的临床疗效及治疗前后患者胃排空率、血清5-HT和Ghrelin的含量.结果:对照组总有效率为79.6％,治疗组为89.4％,两组比较差异有统计学意义(P<0.05).两组治疗后胃排空率和血清Ghrelin含量显著升高,血清5-HT含量明显降低,组内差异均有统计学意义(均P<0.01).治疗组胃排空率和血清Ghrelin含量明显高于对照组,血清5-HT含量明显低于对照组,组间差异均有统计学意义(均P<0.05).血清5-HT水平与胃排空率呈负相关(r=-0.59),血清Ghrelin水平与胃排空率呈正相关(r=0.64),具有统计学意义(均P<0.01).结论:健脾通经止痛膏穴位贴敷治疗肝郁脾虚型功能性消化不良临床疗效显著,并能影响患者血清5-HT和Ghrelin的分泌;通过调节脑肠肽的分泌,从而影响胃肠道运动,可能是其治疗功能性消化不良的潜在作用机制.
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