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1 result(s) for "刘亚楠 耿焱 付炜 彭娜 古正涛 苏磊"
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经典型热射病大鼠恢复期体温变化与预后的关系
目的 构建经典型热射病(HS)大鼠模型,观察恢复期核心体温的调节特征,并分析其与预后的关系。方法 雄性SPF级SD大鼠60只随机分为HS组(n=50)和正常对照组(n=10)。HS组大鼠予39℃热打击,监测核心体温及动脉收缩压(SBP)变化,达到HS诊断标准后结束热打击,观察72h恢复期核心体温的变化特征及生存情况,并对预后因素进行单因素和多因素Cox回归分析。结果 HS组大鼠在热打击后恢复期表现为双相式变化,即发生低体温和迟发性高热。单因素分析显示,HS大鼠最高核心体温、最低核心体温均与预后相关(P〈0.05)。多因素分析显示,HS大鼠最高核心体温(P=0.000,HR=102.386)、恢复期最低核心体温(P=0.001,HR=0.134)为影响HS大鼠预后的独立危险因素。结论 大鼠达到HS时核心体温越高,其发生低体温的程度越深,预后越差。热应激期和恢复期核心体温水平可作为HS大鼠预后的敏感指标。