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1 result(s) for "张大伟 许亮 徐俊楠 詹胜利 李响 袁清 李树欣 蔡明"
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肾移植受者术前甘油三酯代谢对移植肾早期功能恢复的影响
目的 探讨肾移植受者术前甘油三酯(TG)代谢对其移植肾早期功能(EGF)恢复的影响。方法 回顾性分析2011年1月-2014年12月170例在解放军309医院接受活体肾移植受者的临床资料,经排除标准筛选后最终纳入154例受者,其中男124例,女30例,年龄31.9±8.4岁。根据受者术前TG水平分为TG正常组(0.401.70mmol/L或需服用降脂药控制血脂者,n=47),观察两组患者中移植肾功能恢复不佳(PEGF)、肾功能延迟恢复(DGF)和肾功能缓慢恢复(SGF)的发生率,进一步比较移植肾功能顺利恢复(IGF)的两组受者术后3、7及30d的肌酐(Scr)水平。绘制以TG为诊断指标的ROC曲线,以获得预测肾移植术后发生PEGF、SGF、DGF风险的最佳TG值。结果 与TG正常组相比,TG异常组的受者术后PEGF及DGF的发病率较高,差异有统计学意义(P〈0.05)。IGF的受者中,TG异常组术后7、30d的Scr值高于TG正常组,差异有统计学意义(P〈0.05)。术前TG预测PEGF、SGF及DGF的ROC曲线下面积(AUC)分别为0.774、0.704、0.818,均明显大于机会参考下面积(P〈0.05),最佳临界值均为1.37mmol/L。结论 受者术前TG代谢异常对移植肾早期功能恢复可能具有负性影响。术前受者TG在正常高值时(〉1.37mmol/L),其发生PEGF、SGF和DGF的风险便已增加。