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2 result(s) for "涂雪松"
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心房颤动相关性缺血性卒中临床研究现状
心房颤动相关性缺血性卒中临床研究现状
in 心房颤动 , 血小板聚集抑制剂
2015
心房颤动是急性缺血性卒中的独立危险因素,由其引起的缺血性卒中约占全部缺血性卒中的20%;与心房颤动相关的危险因素包括高龄（≥75岁）、高血压、糖尿病、近期心力衰竭、缺血性卒中或短暂性脑缺血发作病史,风险评价体系包括CHADS2和CHA2DS2-VASC评分系统。风险评价体系的建立有利于评价脑卒中风险、决定采取何种治疗措施。预防性治疗原则为高度和中度风险行抗凝治疗、低度风险行抗血小板治疗或不治疗。华法林目前仍是主要抗凝药物,新型口服抗凝药虽具有脑卒中发生率和出血率低、无需监测等优点,但缺乏多中心大样本随机对照试验的验证。
Journal Article
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诱导型多能干细胞在神经变性疾病中的作用
诱导型多能干细胞在神经变性疾病中的作用
in 多能干细胞 , 神经系统疾病 , 细胞分化
2014
诱导型多能干细胞技术是一种通过新的体细胞重编程，将组织细胞转化为可多向分化的细胞即干细胞的技术。目前已将4种转录因子导入人体皮肤纤维母细胞，并首次成功诱导出诱导型多能干细胞。此项技术不但可以建立神经系统疾病动物模型，用于发病机制和致病基因的研究，而且可以开展移植研究，验证疗效及筛选药物。
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