Explore the vast range of titles available.

This study aimed to investigate the prevalence, trends, and predictors of coffee consumption among Saudi female students and its association with anthropometric and demographic variables. A survey-based study using a face-to-face interview was designed, and 930 (aged 21.5 ± 2.1 years) apparently healthy female students from different departments of King Saud University participated. The prevalence of coffee consumption was significantly higher (88.2%, p < 0.03) in the central Riyadh region. Coffee consumers had significantly higher prevalence of being overweight than non-consumers (p = 0.02). The frequency of coffee consumption was significantly higher (p < 0.02) in students who were single and belonged to families with a moderate income level. Coffee consumption was significantly higher among first-year students with a high-scale grade point average (GPA) (p < 0.001 and p = 0.03, respectively). Increased coffee consumption during exam and stress conditions was associated with unhealthy dietary habits such as using more sugar and spices. The prevalence of coffee consumption was high among Saudi females. High body mass index (BMI) and increased family income level were strong determinants for coffee consumption. Continued nutritional education and awareness about the potential positive and negative health effects of coffee consumption and the importance of food label use should be provided to younger generations in order to correct the wrong perceptions.

Introduction. Currently, there are standard and basic versions of the MoCA, the latter designed for those with lower educational achievements. Community-based normative data on these versions of the MoCA from Arabic populations are deficient, and there is little data demonstrating how both scales perform in comparison. We aim to obtain normative performances from both versions and equate the measures of both scales. Methods. Community-based recruitment of healthy volunteers≥18 years of age. Participants underwent testing with both versions. Demographic data was collected with regard to age, gender, years of education, diabetes, and hypertension. Regression analysis was performed to determine significance of variables, and the circle-arc equating method was used to equate the two scores from each scale. Results. 311 participants were included in the study. The mean (sd) age was 45.8 (15.96), females were 184 (59.16%), and the duration of education was 12.7 (5.67) years. The mean scores on the MoCA-A and MoCA-B were 21.47 (4.53) and 24.37 (4.71) (P<0.0001), respectively. Multivariate regression showed significance of age and years of education in both versions (both variables with P<0.0001). Correlation coefficient between the two scales was 0.77 (P<0.0001). The largest equated difference between both MoCA versions was four points in those scoring from 10-20 on the MoCA-A. Conclusion. We present normative data from a large Saudi Arabian community-based sample with two different MoCA tests, and an equating graph is presented to determine the corresponding expected performance between the two scales.

Background: Approximately five million patients on yearly basis are being admitted to the critical care unit around the world. Around (77%) of these patients suffer from pain during their stay in critical care units. Undertreated pain aggravates anxiety, sleep deprivation, agitation, delirium, and depression that often lead to a chronic condition. There are various barriers toward recognition and proper management of pain such as sedation, the presence of endotracheal tube, healthcare providers lack of knowledge etc. Therefore, it becomes essential for the nurses to have the required knowledge related to pain, valid pain assessment tools, and proper management. Objective: The present study aimed at investigating the critical care nurses’ knowledge and attitude towards pain management at a university hospital in Saudi Arabia. Methods: A descriptive cross-sectional design of 112 nurses working at intensive care units and emergency department. The data collected using a knowledge and attitude regarding pain (KASRP) survey. Results: Majority of nurses had inadequate knowledge regarding pain management. Among 112 nurses, only 8 nurses (7.1%) were with good level of knowledge compared by 54 nurses (48.2%) with poor level of knowledge. Results showed significant association between knowledge and attitude and the current position in the ICU (p=0.043). Conclusion: It is mandatory to monitor nurses’ pain management knowledge continuously. As well as to emphasis significance of an educational programs that serve nursing practice.

Rationale: Hepatocyte nuclear factor 1 beta ( HNF1B ) nephropathy is a rare autosomal dominant monogenic kidney disease. We present a case mimicking autosomal dominant polycystic kidney disease (ADPKD), highlighting the phenotypic heterogeneity of HNF1B -related disease. Presenting concerns of the patient: A 37-year-old man presented with hypertensive urgency, accompanied by flank pain and abdominal distension. Despite the absence of familial kidney disease, imaging revealed large bilateral kidney cysts resembling ADPKD. Diagnosis: We initially suspected de novo ADPKD. However, negative genetic testing results for PKD1 and PKD2 led to a 43-gene cystic kidney sequencing panel which identified a deletion encompassing the entire HNF1B gene. Intervention: To alleviate discomfort caused by the kidney cysts, ultrasound-guided aspiration and foam sclerotherapy were performed. Tolvaptan, used for treating high-risk ADPKD, was not prescribed after confirming the diagnosis was HNF1B nephropathy. Outcomes: A diagnosis of HNF1B nephropathy was reached following gene panel testing. Abdominal symptoms improved following cyst aspiration and foam sclerotherapy. Novel findings: HNF1B nephropathy has a variable presentation but can lead to cysts appearing like ADPKD. A 43-gene cystic kidney sequencing panel identified the diagnosis in this uncertain case.

Rationale: Hepatocyte nuclear factor 1 beta (HNF1B) nephropathy is a rare autosomal dominant monogenic kidney disease. We present a case mimicking autosomal dominant polycystic kidney disease (ADPKD), highlighting the phenotypic heterogeneity of HNF1B-related disease. Presenting concerns of the patient: A 37-year-old man presented with hypertensive urgency, accompanied by flank pain and abdominal distension. Despite the absence of familial kidney disease, imaging revealed large bilateral kidney cysts resembling ADPKD. Diagnosis: We initially suspected de novo ADPKD. However, negative genetic testing results for PKD1 and PKD2 led to a 43-gene cystic kidney sequencing panel which identified a deletion encompassing the entire HNF1B gene. Intervention: To alleviate discomfort caused by the kidney cysts, ultrasound-guided aspiration and foam sclerotherapy were performed. Tolvaptan, used for treating high-risk ADPKD, was not prescribed after confirming the diagnosis was HNF1B nephropathy. Outcomes: A diagnosis of HNF1B nephropathy was reached following gene panel testing. Abdominal symptoms improved following cyst aspiration and foam sclerotherapy. Novel findings: HNF1B nephropathy has a variable presentation but can lead to cysts appearing like ADPKD. A 43-gene cystic kidney sequencing panel identified the diagnosis in this uncertain case.

An exploratory descriptive survey with a correlational design examined the risk factors for cardiovascular disease among a convenience sample of university students at Heriot-Watt University, Edinburgh. The first survey, with 156 students, identified several risk factors, including obesity, low of physical inactivity, consumption of alcohol and soft drinks with extrinsic sugars, not eating fruit and vegetables, and smoking tobacco. The second survey, with 40 students, provided more detailed information on dietary factors analysed by cluster and principal component analysis. The students were classified into four groups. One group (7.5% of the students) exhibited the greatest level of risk factors, including the highest BMI, body fat, waist to hip ratio, blood pressure, LDL-cholesterol, fasting glucose, the lowest HDL cholesterol, the highest mean intake of alcohol, chloride saturated fatty acids and total sugars and intake of dietary fibre. The relationships between the risk factors were revealed by a structural equation model with a moderate effect size (R2 = 48.9%). This model indicated that the BMI, body fat, and waist to hip ratio were higher if the students were smokers and consumed large amounts of alcohol, saturated fatty acids, salt, and sugars. The anthropometric measurements were also higher if the students had high levels of blood pressure, blood glucose, and LDL-cholesterol. The anthropometric measures were lower if the students consumed high amounts of dietary fibre, consumed at least five servings of fruit and vegetables every day, and had a high level of physical activity. More research and education including a health education programme based on a plan-do-study-act cycle is recommended to improve student awareness of their exposure to multiple risk factors for cardiovascular disease, and to determine how these risk factors can be alleviated in the future.

The vision of next generation wireless network (NGWN) is to integrate different wireless access technologies, each with its own characteristics, into a common IP-based core network to provide mobile user with service continuity and seamless roaming. One of the major issues for the converged heterogeneous networks is providing a seamless vertical handover (VHO) with QoS support. In this paper we have reviewed the various interworking architectures and handover scenarios between UMTS and WiMAX. Also, we have compared the proposed solutions based on different criteria and revealed the pros and cons of each scheme. The comparison aids to adopt a better interworking and handover mechanism in NGWN.

Colon cancer (CC) is a significant cause of death worldwide, particularly in Saudi Arabia. To increase the accuracy of diagnosis and treatment, it is important to discover new specific biomarkers for CC. The main objectives of this research are to identify potential specific biomarkers for the early diagnosis of CC by analyzing the expressions of eight cancer testis (CT) genes, as well as to analyze how epigenetic mechanisms control the expression of these genes in CC cell lines. Tissue samples were collected from 15 male patients with CC tissues and matched NC tissues for gene expression analysis. The expression levels of specific CT genes, including ADAD1 , DMRTC2 , PRSS54 , SYCE1 , SYCP1 , TEX101 , TEX48 , and TMPRSS12 , were assessed using quantitative techniques. To validate the gene expression patterns, we used publicly available CC statistics. To investigate the effect of inhibition of DNA methylation and histone deacetylation on CT gene expression, in vitro experiments were performed using HCT116 and Caco-2 cell lines. There was no detected expression of the genes neither in the patient samples nor in NC tissues, except for TEX48 , which exhibited upregulation in CC samples compared to NC tissues in online datasets. Notably, CT genes showed expression in testis samples. In vitro , experiments demonstrated significant enhancement in mRNA expression levels of ADAD1 , DMRTC2 , PRSS54 , SYCE1 , SYCP1 , TEX101 , TEX48 , and TMPRSS12 following treatment with 5-aza-2’-deoxycytidine and trichostatin A in HCT116 and Caco-2 cell lines. Epigenetic treatments modify the expression of CT genes, indicating that these genes can potentially be used as biomarkers for CC. The importance of conducting further research to understand and target epigenetic mechanisms to improve CC treatment cannot be overemphasized.

Listeriosis is a severe zoonotic disease caused by Listeria monocytogenes ( L. monocytogenes ), which can be acquired through animal source foods. This pathogen shows unique virulence fitness allowing it to penetrate and survive inside host cells causing extremely dangerous symptoms. Therefore, we aimed to correlate the clinical outcomes with the antimicrobial resistance and virulence profiles of L. monocytogenes . This is crucial for improving disease management, developing new therapeutic strategies, enhancing public health and food safety, and advancing scientific knowledge. Therefore, we assessed the antimicrobial resistance and virulence profiles of L. monocytogenes isolated from various sources, along with their potential to cause disease, using an in vivo rabbit model. Based on identification criteria, 47 L. monocytogenes isolates (15.7%) were recovered with the highest detection rates among rabbits (22%). Unfortunately, all the investigated isolates showed multidrug resistance (MDR) as well as multi-virulent profiles with 45 highly heterogeneous clusters. Noteworthy, the degree of illnesses of the experimentally infected rabbits was dependent on the virulence profiles. Specific nervous manifestations and severe histopathological alterations were observed in experimental rabbits infected with highly virulent isolates confirming that the potential ability of this pathogen to produce a disease is not always decipherable from its virulence arrays. Finally, it was confirmed that managing infections caused by L. monocytogenes has become increasingly challenging due to its high antimicrobial resistance, strong virulence, and the severe pathological effects linked to its virulence factors.