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Today, digitalization decisively penetrates all the sides of the modern society. One of the key enablers to maintain this process secure is authentication. It covers many different areas of a hyper-connected world, including online payments, communications, access right management, etc. This work sheds light on the evolution of authentication systems towards Multi-Factor Authentication (MFA) starting from Single-Factor Authentication (SFA) and through Two-Factor Authentication (2FA). Particularly, MFA is expected to be utilized for human-to-everything interactions by enabling fast, user-friendly, and reliable authentication when accessing a service. This paper surveys the already available and emerging sensors (factor providers) that allow for authenticating a user with the system directly or by involving the cloud. The corresponding challenges from the user as well as the service provider perspective are also reviewed. The MFA system based on reversed Lagrange polynomial within Shamir’s Secret Sharing (SSS) scheme is further proposed to enable more flexible authentication. This solution covers the cases of authenticating the user even if some of the factors are mismatched or absent. Our framework allows for qualifying the missing factors by authenticating the user without disclosing sensitive biometric data to the verification entity. Finally, a vision of the future trends in MFA is discussed.

Heat-treatment furnaces for workpiece pre-rolling heating are heating plants of the transition type where sheet slabs with various characteristics are simultaneously heated. The heat treatment furnace performance is directly connected with the efficient operation of the rolling mill process plants. The irregular operation pace of the rolling mill complicates the implementation of energy-saving workpiece pre-rolling heating modes and increases the risk of delivering an insufficiently heated workpiece. This paper proposes the system of controlling the heat mode of the heat-treatment furnace by the criterion of fuel consumption rate minimization and controlling over a real heated state of a sheet slab located at the workpiece pushing from the heat-treatment furnace to the rolling mill. The author uses a simplified mathematical model of workpiece heating intended for defining the energy-saving heating path accounting for the impact of technological and structural constraints in the workpiece heating process. The calculation is conducted in real time and allows obtaining an optimal heating path of each workpiece at the moment of its loading into the heat-treatment furnace. The paper considers the necessity of interaction and the interaction itself of the subsystems performing the key function in the energy-saving operation mode of the heat-treatment furnace at workpiece heating. The author studied the subsystems of forecasting the workpiece heating time on the state of the rolling mill equipment and the geometrical dimensions of the rolled band, control over gaseous fuel burning in the heat-treatment furnace operation space, system of control over the workpiece heating state before pushing from the heat-treatment furnace and forecasting the roll temperature after the treatment of the rolling mill roughing train.

Biogenic amines (BAs) can be found in various foods, such as cheese, wine, and chocolate. The consumption of a sufficient quantity of BA can lead to symptoms including headaches, hypertonia, and diarrhea. For this reason, the amount of BA in food is regulated in many countries. A new method for the determination of biogenic amines in wine has been proposed, which involves derivatizing BA with p-toluene sulfonyl chloride (TsCl) and using K2S2O8 to reduce the matrix effect. The derivatives of putrescine, cadaverine, histamine, and tyramine with TsCl were synthesized and characterized by 1H NMR spectroscopy. Separation of BA derivatives was performed using a reversed-phase high-performance liquid chromatography (RP-HPLC). The chromatographic system was equipped with a reversed-phase C8 column and a diode array detector. This method was validated to analyze the above-mentioned biogenic amines simultaneously in red and white wine samples. The detection limits for putrescine, cadaverine, histamine, and tyramine in wine samples were 0.0248 mg·L−1, 0.0645 mg·L−1, 0.346 mg·L−1 and 0.00866 mg·L−1, respectively. The calibration curves showed good linearity (r > 0.999), and biogenic amines recovery varied from 83.0 to 110%. The proposed method demonstrates high sensitivity, straightforward sample preparation, and rapid analysis time.

The unprecedented growth of today’s cities together with increased population mobility are fueling the avalanche in the numbers of vehicles on the roads. This development led to the new challenges for the traffic management, including the mitigation of road congestion, accidents, and air pollution. Over the last decade, researchers have been focusing their efforts on leveraging the recent advances in sensing, communications, and dynamic adaptive technologies to prepare the deployed road traffic management systems (TMS) for resolving these important challenges in future smart cities. However, the existing solutions may still be insufficient to construct a reliable and secure TMS that is capable of handling the anticipated influx of the population and vehicles in urban areas. Along these lines, this work systematically outlines a perspective on a novel modular environment for traffic modeling, which allows to recreate the examined road networks in their full resemblance. Our developed solution is targeted to incorporate the progress in the Internet of Things (IoT) technologies, where low-power, embedded devices integrate as part of a next-generation TMS. To mimic the real traffic conditions, we recreated and evaluated a practical traffic scenario built after a complex road intersection within a large European city.

Hair loss (alopecia) is a common disorder caused by an interruption in the body’s cycle of hair production. This pathology negatively affects the psychoemotional state of patients and significantly reduces their quality of life. The currently available medical treatments (including minoxidil therapy) are effective in arresting the progression of the disease; however, they allow only partial regrowth of hair at best. A significant clinical result occurs only with regular drug use. There is still great interest in finding new drugs for the treatment of alopecia. In this study, we aimed to examine the effect of an aqueous dispersion of unmodified fullerene C60 (ADF) on hair growth. ADF, produced by a unique technology, is biocompatible and non-toxic. Nu/nu mice were subcutaneously injected (2 μg/animal) every two days for a period of 11 days with ADF and, for control purposes, with phosphate-buffered saline (PBS). It was shown that ADF stimulated hair growth. Histological analysis of the nu/nu mice skin areas showed that animals treated with ADF had significantly more (about twice as many) hair follicles in the anagen phase compared to mice treated with PBS. The effect on hair growth persisted even after discontinuation of ADF administration. Analysis of gene expression demonstrated that ADF affected the Wnt-signaling pathway, increased the expression of the Wnt10b (wingless-type Mouse Mammary Tumor Virus integration site family, member 10B) factor, angiogenetic factors, and downregulated tumor necrosis factor-alpha levels. We propose that the mechanism of ADF action is likely related to its ability to attract macrophages to the hair follicle microenvironment and promote their polarization to the M2 phenotype. In addition, using molecular modeling, we tried to substantiate our hypothesis about the interaction of ADF with the adenosine A2A receptor, which may cause a decrease in tumor necrosis factor-alpha production. Thus, ADF may become a promising drug for the development of new approaches to the treatment of alopecia associated with immune disorders.

Every year, millions of hectares burn across Siberia, driven by a combination of warming temperatures, regional drought and human-caused ignitions. Dendrochronology provides a long-term context to evaluate recent trends in fire activity and interpret the relative influence of humans and climate drivers on fire regimes. We developed a 400 year record of fire-scarred trees from 17 sites in pine-dominated forests located southeast of Lake Baikal. Site-level mean fire return intervals (MFIs) ranged from 4 to 27 years for all fires and 8 to 35 years for widespread fires within sites. Sites with the lowest MFI values were located within 1 km of agricultural fields in grassland valleys, suggesting that agricultural burning influenced MFIs at nearby sites. Fire frequency varied over the record, with significantly high values around 1790, from 1865 to 1880, 1948 to 1955 and 1995 to 2005. The increased fire activity corresponded with migration waves to the region and major socio-economic change connected with the establishment and breakdown of the Soviet Union. At broader scales, superposed epoch analysis showed that synchronous fire years were associated with regional drought and precipitation deficits. Wet conditions for 2–3 years prior to the event year were also significant, suggesting that increased moisture promoted growth of understory fine fuels to support more extensive fires across the study area. Although fire frequencies increased during the 20th century, fire–climate relationships weakened, suggesting increased human-caused ignitions may override regional climate drivers. Our dataset presents a continuous record of frequent surface fires over the past 400 years, providing a valuable opportunity to compare dendrochronology-based reconstructions with satellite and documentary records.

The authors propose an experimental search optimization strategy for power consumption control of electric arc production units to maintain their maximum capacity. An EAF-180 modern high-power electric arc furnace is used as an example. The efficient and intelligent optimization of extremal control of electric power consumption at maximum capacity is facilitated by an extremum search method that stores the active power change rate extremum and stops at a set search time when the process reaches an optimal mode. Use of the proposed search method ensures high reliability of electrode transfer operation by near-complete exclusion of a periodic operation mode which is characteristic of known search methods. Bench-scale testing of the search optimizing extremal control was conducted on a computer-based unit representing a single-phase electric arc furnace. The proposed search method focuses on the application of software and regulating microprocessor controllers, does not require considerable expense, and almost fully excludes interference by process personnel in the power consumption control mode of an electric arc furnace.

Background/Objectives: Biological aging phenotypes in coronary artery disease (CAD) include coronary atherosclerosis, vascular aging, and endothelial dysfunction. The aim of the present study was to investigate the potential links between aging phenotypes, regulatory immune cells, and features of the thymus in patients with CAD. Methods: A single-center, cross-sectional, comparative study was conducted. Patients were stratified according to the severity of coronary atherosclerosis: patients with a Gensini score ≥ 65 points and patients with a Gensini score < 65 points. Peripheral blood and thymus biopsy were obtained. Imaging flow cytometry, ELISA, and immunohistochemical analysis were used for analysis. Results: Thymic morphology ranged from total fatty involution to a preserved structure of the thymus (20–80% area in 31% of obtained samples) but was not associated with the severity of atherosclerosis. Meanwhile, patients with a Gensini score ≥ 65 had impaired thymus cellular composition compared to patients with a Gensini score < 65 points; increased frequency of CD8+ T lymphocytes and NK cells; and decreased frequency of CD4 + CD8+ T lymphocytes. In peripheral blood, the main determinants of a Gensini score ≥ 65 points were low absolute counts of eMDSCs and CD25low Tregs with FoxP3 nuclear translocation, while advanced vascular aging was associated with elevated eMDSC absolute counts. Advanced coronary atherosclerosis was also associated with decreased numbers of endothelial progenitor cells in circulation. Conclusions: Thymus dysfunction accompanies CAD progression and is manifested in changes in cellular composition rather than morphology. In CAD patients, MDSC and Treg lymphocytes are equally involved in the progression of coronary atherosclerosis, which is aggravated by the decreased regulatory potential of the endothelium. Vascular aging represents a distinct phenotype of biological aging in CAD patients, characterized by the expansion of eMDSCs.

In this study, we report an easy approach for the production of aqueous dispersions of C60 fullerene with good stability. Maleic acid copolymers, poly(styrene-alt-maleic acid) (SM), poly(N-vinyl-2-pyrrolidone-alt-maleic acid) (VM) and poly(ethylene-alt-maleic acid) (EM) were used to stabilize C60 fullerene molecules in an aqueous environment by forming non-covalent complexes. Polymer conjugates were prepared by mixing a solution of fullerene in N-methylpyrrolidone (NMP) with an aqueous solution of the copolymer, followed by exhaustive dialysis against water. The molar ratios of maleic acid residues in the copolymer and C60 were 5/1 for SM and VM and 10/1 for EM. The volume ratio of NMP and water used was 1:1.2–1.6. Water-soluble complexes (composites) dried lyophilically retained solubility in NMP and water but were practically insoluble in non-polar solvents. The optical and physical properties of the preparations were characterized by UV-Vis spectroscopy, FTIR, DLS, TGA and XPS. The average diameter of the composites in water was 120–200 nm, and the ξ-potential ranged from −16 to −20 mV. The bactericidal properties of the obtained nanostructures were studied. Toxic reagents and time-consuming procedures were not used in the preparation of water-soluble C60 nanocomposites stabilized by the proposed copolymers.

Several virus-neutralizing monoclonal antibodies (mAbs) have become new tools in the treatment of the coronavirus disease (COVID-19), but their effectiveness against the rapidly mutating virus is questionable. The present study investigated the effectiveness of Tixagevimab/Cilgavimab and Regdanvimab for mild and moderate COVID-19 treatment in real-world clinical practice during the Omicron variant-dominant period. Patients with known risk factors for disease progression and increasing disease severity were enrolled in the study within the first 7 days of symptom onset. Seventy-seven patients were divided into four groups: first 15 patients received 300 mg Tixagevimab/Cilgavimab intravenously (IV) and 23 patients got the same drug 300 mg intramuscularly (IM), the next 15 patients was on the same combination in dose of 600 mg IV, and 24 patients were on Regdanvimab at a dose of 40 mg/kg IV. By Day 4, 100% of Tixagevimab/Cilgavimab IV patients showed negative polymerase chain reaction results for SARS-CoV-2 Ribonucleic acid (RNA) regardless of the mAbs dose while in the Regdanvimab group 29% of the patients were positive for SARS-CoV-2 virus RNA. The testing for virus neutralizing antibodies (nAbs) to various Omicron sublineages (BA.1, BA.2, and BA.5) showed that an increase in nAb levels was detected in blood serum immediately after the drug administration only in Tixagevimab/Cilgavimab 300 mg and 600 mg IV groups. In the group of intravenous Regdanvimab, a significant increase in the level of nAbs to the Wuhan variant was detected immediately after the drug administration, while no increase in nAbs to different Omicron sublineages was observed.