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"Arnold, Cath"
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Improving Your Reflective Practice through Stories of Practitioner Research
Improving Your Reflective Practice through Stories of Practitioner Research shows how research has informed and created effective and valuable reflective practice in early years education, and offers depth to the arguments for a research-orientated stance to this vital field of study.
This thought-provoking text explores and documents a variety of small-scale practitioner research projects from the home and early years settings. The stories are centred around real life for children, families and workers and offer practical ideas and support for early years students around the world. They engage in some of the most current debates in early childhood education today, such as:
how to support children as individuals
how young children learn and how parents support their learning
how to lead and facilitate change in a way that does not take power away from children, parents or workers
how to support children in taking risks
how to support parents in returning to learning.
Throughout this book, the 'Pen Green' attitude to practitioner research is actively encouraged. This involves fostering curiosity, being open to the views of others, questioning the 'taken for granted', making the implicit explicit and reflecting on one's daily work. Any practitioner research in early years education and care will draw inspiration from this accessible and supportive text.
eBook
Observing Harry
\"the book shows quite powerfully...how a well-resourced and flexible learning environment can be exploited by children to channel their interests and expand their understanding...As well as contributing to our understanding of learning, it should also serve.
eBook
Elucidation of the outer membrane proteome of Salmonella enterica serovar Typhimurium utilising a lipid-based protein immobilization technique
Background
Salmonella enterica
serovar Typhimurium (
S
. Typhimurium) is a major cause of human gastroenteritis worldwide. The outer membrane proteins expressed by
S
. Typhimurium mediate the process of adhesion and internalisation within the intestinal epithelium of the host thus influencing the progression of disease. Since the outer membrane proteins are surface-exposed, they provide attractive targets for the development of improved antimicrobial agents and vaccines. Various techniques have been developed for their characterisation, but issues such as carryover of cytosolic proteins still remain a problem. In this study we attempted to characterise the surface proteome of
S
. Typhimurium using Lipid-based Protein Immobilisation technology in the form of LPI™ FlowCells. No detergents are required and no sample clean up is needed prior to downstream analysis. The immobilised proteins can be digested with proteases in multiple steps to increase sequence coverage, and the peptides eluted can be characterised directly by liquid chromatography - tandem mass spectrometry (LC-MS/MS) and identified from mass spectral database searches.
Results
In this study, 54 outer membrane proteins, were identified with two or more peptide hits using a multi-step digest approach. Out of these 28 were lipoproteins, nine were involved in transport and three with enzyme activity These included the transporters BtuB which is responsible for the uptake of vitamin B
12
, LamB which is involved in the uptake of maltose and maltodextrins and LolB which is involved in the incorporation of lipoproteins in the outer membrane. Other proteins identified included the enzymes MltC which may play a role in cell elongation and division and NlpD which is involved in catabolic processes in cell wall formation as well as proteins involved in virulence such as Lpp1, Lpp2 and OmpX.
Conclusion
Using a multi-step digest approach the LPI™ technique enables the incorporation of a multi-step protease work flow ensuring enough sequence coverage of membrane proteins subsequently leading to the identification of more membrane proteins with higher confidence. Compared to current sub-cellular fractionation procedures and previous published work, the LPI™ technique currently provides the widest coverage of outer membrane proteins identified as demonstrated here for
Salmonella
Typhimurium.
Journal Article
Young Children Learning Through Schemas
Young Children Learning Through Schemas is a creative and highly engaging text that shows how young children can learn through exploring repeated patterns in their actions. With contributions from a range of practitioners, this book examines the philosophical approaches underpinning constructivism and includes a variety of case studies of small children in order to demonstrate the universal explorations we all engage in as human beings.
This approach from the contributors, which involves presenting observations of one or two young children per chapter, is engaging, inspirational and yet rooted in every day practice. Chapters include a variety of observations of young children at home, in nursery and in groups with their parents or carers, which continue the dialogue about early years practice and the roles of families and professionals. Containing a wealth of illustrative photos, any practitioner researching or working in the area of Early Years education and care will find this book essential reading.
eBook
Child Development and Learning 2-5 Years
This book grew out of a three-year study of one child, documenting her social, emotional and cognitive development. It provides a valuable insight for all students and teachers of child development at the individual level. The observations and assessments are presented here as a model for students to use in their own observations aimed at supporting and extending children's learning. The book sets out theories and traditions in early childhood development and care, as well as ways of analyzing observations. This is an essential book for students and practitioners involved in research and observation in early years settings.
eBook
Child development and learning, 2-5 years: Georgia's story
`This book is a welcome contribution to the literature available for early years practitioners. The clear focus on one child is an excellent antidote to the current risks of focusing so much on the general framework and learning goals for all, that we lose sight of how individual children negotiate the early years' - Nursery World This book grew out of a three-year study of one child, documenting her social, emotional and cognitive development. It provides a valuable insight for all students and teachers of child development at the individual level. The observations and assessments are presented here as a model for students to use in their own observations aimed at supporting and extending children's learning. The book sets out theories and traditions in early childhood development and care, as well as ways of analyzing observations. This is an essential book for students and practitioners involved in research and observation in early years settings.
eBook
Observing Harry : child development and learning 0-5
\"the book shows quite powerfully ...how a well-resourced and flexible learning environment can be exploited by children to channel their interests and expand their understanding. As well as contributing to our understanding of learning, it should also serve. to inform debate about gaining children's consent in the research process.\"Early Years This book is about Harry, a determined little boy, who is intrinsically motivated to explore his world from an early age. His parents and grandparents find him so fascinating that they keep a written and video diary of Harry's play from when he is 8 months to five years. The author offers theories about how children learn and applies the theories to the observations of Harry. The book demonstrates how effectively Harry accesses each area of the curriculum through his interests. It shows how Harry develops coping strategies when the family experiences major changes. It also highlights the contribution made by Harry's parents and his early years educators to his early education. Much of what we learn about Harry's early learning can be applied to many other young children. This book about one child's early development and learning will be of interest to all who are fascinated by how young children learn - nursery practitioners, early years teachers, parents, students and advisers.
eBook
Evolution of short sequence repeats in Mycobacterium tuberculosis
Abstract
Whole genome comparison has revealed the presence of short sequence repeats (also called mycobacterial interspersed repeat units and variable number tandem repeat units) used for genotyping schemes. In this study, we have used deletion analysis, single nucleotide polymorphism data and spoligotype taken from published data from others to investigate the evolution of selected repeats that form the common denominators of the majority of established schemes. Analysis of the number of repeats per locus from over 400 isolates revealed that the general trend globally appears to be loss of repeats in modern strains compared with ancestral strains.
Journal Article