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The fabrication of scaffolds for bone tissue engineering (BTE) applications often involves the utilization of two distinct categories of biomaterials, namely calcium phosphates and calcium silicates. The selection of these materials is based on their biocompatibility, bioactivity, and mechanical characteristics that closely resemble those of natural bone. The present research examined the utilization of hydroxyapatite (HAP) and tri-calcium silicate (TCS), which are among the most commonly utilized materials in calcium phosphates and calcium silicates, in the context of bone scaffolding applications. A molecular dynamics simulation was conducted to investigate the impact of different concentrations of ceramic nanoparticles, when combined with sodium alginate (SA) hydrogel, on the fabrication of bone scaffolds. The stability and self-assembly were assessed through several parameters, such as the solvent-accessible surface area (SASA), radius of gyration (Rg), radial distribution function (g(r)), root-mean-square deviation (RMSD), root-mean-square fluctuation (RMSF), hydrogen bonding, van der Waals, electrostatic, and total energies. The findings indicate that the addition of 10 wt% HAP and TCS to the SA hydrogel matrix results in a more compact, stable, and potentially less hydrated structure. Accordingly, the experimental validation of these simulation approved our in silico findings. Experimental rheology and mechanical properties evaluation validate our simulation results, indicating a superior characteristic of TCS10 and HAP10 inks and 3D-printed scaffolds among other composition ratios. This could potentially benefit the in vitro and in vivo performance of the scaffold and its interaction with cells. The aforementioned traits are considered fundamental for the successful execution of the scaffold in the field of BTE. The findings indicate that TCS samples exhibit superior properties when compared to HAP samples, specifically in terms of composition with SA hydrogel.

In this study, L-arginine (Arg) modified magnetite (Fe3O4) nanoparticles (RMNPs) were firstly synthesized through a one-step co-precipitation method, and then these aminated nanoparticles (NPs) were, again, coated by pre-oxidized dextran (Dext), in which aldehyde groups (DextCHO) have been introduced on the polymer chain successfully via a strong chemical linkage. Arg, an amino acid, acts as a mediator to link the Dext to a magnetic core. The as-synthesized Arg-modified and Dext-coated arginine modified Fe3O4 NPs were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transformation infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), and vibrating sample magnetometer (VSM). Both synthesized samples, XRD pattern and FT-IR spectra proved that the core is magnetite. FT-IR confirmed that the chemical bonds of Arg and Dext both exist in the samples. SEM images showed that the NPs are spherical and have an acceptable distribution size, and the VSM analysis indicated the superparamagnetic behavior of samples. The saturation magnetization was decreased after Dext coating, which confirms successive coating RMNPs with Text. In addition, the TGA analysis demonstrated that the prepared magnetic nanocomposites underwent various weight loss levels, which admitted the modification of magnetic cores with Arg and further coating with Dext.