Journal Article

Covalently-Bonded Coating of L-Arginine Modified Magnetic Nanoparticles with Dextran Using Co-Precipitation Method

Yazdanpanah, Roozbeh, Azadpour, Behnam, Kashanian, Faezeh, Hamawandi, Bejan, Habibi-Rezaei, Mehran, Seyyed Ebrahimi, Seyyed Ali, Lalegani, Zahra

2022

Overview

In this study, L-arginine (Arg) modified magnetite (Fe3O4) nanoparticles (RMNPs) were firstly synthesized through a one-step co-precipitation method, and then these aminated nanoparticles (NPs) were, again, coated by pre-oxidized dextran (Dext), in which aldehyde groups (DextCHO) have been introduced on the polymer chain successfully via a strong chemical linkage. Arg, an amino acid, acts as a mediator to link the Dext to a magnetic core. The as-synthesized Arg-modified and Dext-coated arginine modified Fe3O4 NPs were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transformation infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), and vibrating sample magnetometer (VSM). Both synthesized samples, XRD pattern and FT-IR spectra proved that the core is magnetite. FT-IR confirmed that the chemical bonds of Arg and Dext both exist in the samples. SEM images showed that the NPs are spherical and have an acceptable distribution size, and the VSM analysis indicated the superparamagnetic behavior of samples. The saturation magnetization was decreased after Dext coating, which confirms successive coating RMNPs with Text. In addition, the TGA analysis demonstrated that the prepared magnetic nanocomposites underwent various weight loss levels, which admitted the modification of magnetic cores with Arg and further coating with Dext.

• Publisher: MDPI AG,MDPI
• Subject: Aldehydes / Amino acids / Arginine / Biocompatibility / Chemical bonds / co-precipitation method / Coating / Coatings / Contrast agents / Coprecipitation / Dextran / Dextrans / Diffraction / FDA approval / Fourier transforms / Glass substrates / Hyperthermia / Infrared analysis / Infrared spectroscopy / Iron oxides / L-arginine / Magnetic cores / Magnetic fields / magnetic nanocomposties / Magnetic resonance imaging / Magnetic saturation / Magnetite / magnetite nanoparticles / Magnetization / Magnetometers / Methods / multi-functionalized nanoparticles / Nanocomposites / Nanoparticles / Proteins / Scanning electron microscopy / Silicon wafers / Synthesis / Thermogravimetric analysis / Weight loss / X-ray diffraction / X-rays