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The illustrated children's literature book involves the interaction between written text and image, configuring it as a powerful tool for promoting visual literacy and training readers. Photography as an illustration, added to the materiality of the printed book, can contribute to the development of the literary reader's skills, expanding the possibilities of rapprochement between the reader and the work, based on handling and interaction with the tangible object. This article features a segment from an ongoing doctoral study, its methodology is a qualitative bibliographic analysis and its goal is to discuss photographic illustration, the materiality of the printed book and the metafictional proposal of the narrative as devices that contribute to the approximation between the reader and the work. As a result, it is considered that the choice of photography, associated with the materiality of the book, is capable of expanding dialogues and interpretations, enhancing the training readers. KEYWORDS: Children's literature, Illustration, Photography, Materiality, Metafiction O livro de literatura infantil ilustrado envolve a interacao texto escrito e imagem, configurando-o como uma poderosa ferramenta para a promocao da literacia visual e para a formacao de leitores. A fotografia como ilustracao, somada a materialidade do livro impresso, pode contribuir para o desenvolvimento das competencias do leitor literario, ampliando as possibilidades de aproximacao entre o leitor e a obra, a partir do manuseio e da interacao com o objeto palpavel. Este artigo apresenta um recorte de um estudo de doutoramento em curso, tem como metodologia uma analise bibliografica de cunho qualitativo e como objetivo discutir a ilustracao fotografica, a materialidade do livro impresso e a proposta metaficcional da narrativa como artificios que contribuem para a aproximacao entre o leitor e a obra. Como resultados, considera-se que a escolha pela fotografia, associada a materialidade do livro, se mostra capaz de ampliar dialogos e interpretacoes, favorecendo a formacao de leitores. PALAVRAS-CHAVE: Literatura infantil, Ilustracao, Fotografia, Materialidade, Metaficcao

Organizado pelas Prof. Ângela Balça (Universidade de Évora, Portugal), Prof. Verónica Pontes (IFRN, Brasil) e pelo Prof. Fernando Azevedo (Universidade do Minho, Portugal), o dossier que aqui se apresenta reúne contribuições de diversos autores de várias instituições e continentes, oferecendo uma visão abrangente, interdisciplinar e diversificada sobre o tema. Recuperado de https://www2.ifrn.edu.br/ojs/index.php/HOLOS/article/view/18423 Magalhães Naves, L., & Balça, Ângela. THE BOOK AND COLOURS DESIGNED FOR EARLY CHILDHOOD.

O livro de literatura infantil ilustrado envolve a interação texto escrito e imagem, configurando-o como uma poderosa ferramenta para a promoção da literacia visual e para a formação de leitores. A fotografia como ilustração, somada à materialidade do livro impresso, pode contribuir para o desenvolvimento das competências do leitor literário, ampliando as possibilidades de aproximação entre o leitor e a obra, a partir do manuseio e da interação com o objeto palpável. Este artigo ilustra um recorte de uma pesquisa de doutoramento em curso, tem como metodologia uma análise bibliográfica de cunho qualitativo e como objetivo discutir a ilustração fotográfica, a materialidade do livro impresso e a proposta metaficcional da narrativa como artifícios que contribuem para a aproximação entre o leitor e a obra. Como resultados, considera-se que a escolha pela fotografia, associada à materialidade do livro, se mostra capaz de ampliar diálogos e interpretações, favorecendo a formação de leitores. The illustrated children's literature book involves the interaction between written text and image, configuring it as a powerful tool for promoting visual literacy and training readers. Photography as an illustration, added to the materiality of the printed book, can contribute to the development of the literary reader's skills, expanding the possibilities of rapprochement between the reader and the work, based on handling and interaction with the tangible object. This article illustrates a part from ongoing doctoral research, its methodology is a qualitative bibliographic analysis and its goal is to discuss photographic illustration, the materiality of the printed book and the metafictional proposal of the narrative as devices that contribute to the approximation between the reader and the work. As a result, it is considered that the choice of photography, associated with the materiality of the book, is capable of expanding dialogues and interpretations, enhancing the training readers. El libro de literatura infantil ilustrada implica la interacción del texto escrito y la imagen, configurándolo como una poderosa herramienta para promover la alfabetización visual y formar lectores. La fotografía como ilustración, sumada a la materialidad del libro impreso, puede contribuir al desarrollo de las habilidades del lector literario, ampliando las posibilidades de acercamiento entre el lector y la obra, a partir del manejo e interacción con el objeto tangible. Este artículo ilustra un extracto de una investigación doctoral en curso, su metodología es un análisis bibliográfico cualitativo y tiene como objetivo discutir la ilustración fotográfica, la materialidad del libro impreso y la propuesta metaficcional de la narrativa como dispositivos que contribuyen al acercamiento entre el lector y la obra. Como resultado, se considera que la elección de la fotografía, asociada a la materialidad del libro, es capaz de ampliar diálogos e interpretaciones, favoreciendo la formación de los lectores. Le livre illustré de littérature jeunesse implique l'interaction du texte écrit et de l'image, le configurant comme un outil puissant pour promouvoir l'alphabétisation visuelle et former les lecteurs. La photographie en tant qu'illustration, ajoutée à la matérialité du livre imprimé, peut contribuer au développement des compétences du lecteur littéraire, en élargissant les possibilités de rapprochement entre le lecteur et l'œuvre, basées sur la manipulation et l'interaction avec l'objet tangible. Cet article illustre un extrait d'une recherche doctorale en cours, sa méthodologie est une analyse bibliographique qualitative et son objectif est de discuter de l'illustration photographique, de la matérialité du livre imprimé et de la proposition métafictionnelle du récit comme dispositifs contribuant au rapprochement entre le lecteur et l'œuvre. De ce fait, on considère que le choix de la photographie, associé à la matérialité du livre, est capable d'élargir les dialogues et les interprétations, favorisant la formation des lecteurs.  

To evaluate the effectiveness of an intrauterine hyaluronic acid-based barrier gel in reducing postoperative intrauterine adhesions (IUAs) following hysteroscopic myomectomy for large submucosal myomas. This retrospective study reviewed the medical records of 62 women who underwent hysteroscopic myomectomy for submucosal myomas ≥3 cm between January 2022 and June 2025. Thirty-three patients received intrauterine application of a hyaluronic acid-based barrier gel at the end of surgery, while 29 patients received no anti-adhesion barrier. The was the incidence and severity of postoperative IUAs, assessed by second-look hysteroscopy at 12 weeks using the American Fertility Society scoring system. Secondary outcomes included postoperative menstrual characteristics (PBAC scores), cyclic pelvic pain, and endometrial thickness. Baseline demographic and clinical characteristics were comparable between groups. The incidence of IUAs was significantly lower in the hyaluronic acid gel group compared with controls (6.1% vs 31.0%; p=0.01). The mean total adhesion score was also significantly reduced (0.27 ± 0.89 vs 1.52 ± 2.13; p=0.031). Moderate or severe adhesions occurred only in the control group, although this difference did not reach statistical significance. Postoperative menstrual outcomes and cyclic pelvic pain rates were similar between groups. Endometrial thickness at follow-up tended to be higher in the gel group (7.2 ± 0.9 vs 6.8 ± 0.8 mm; p=0.07). Intrauterine administration of a hyaluronic acid-based barrier gel following hysteroscopic myomectomy for large submucosal myomas significantly reduces the incidence and severity of postoperative intrauterine adhesions, supporting its use as an effective strategy to optimize postoperative uterine cavity outcomes.

During Turkey’s Gezi Park Protests in the summer of 2013, millions of people became connected as fellow pro- testers. In the early days of the Gezi movement, the increase in participatory activism through social media made visible the police brutality exercised in the last days of May 2013 against a small group of environmentalists who were protecting Gezi Park from being demolished in order to build a shopping mall. Throughout Turkey’s political history, there has been no other example of this kind of spontaneous mass movement resisting the state apparatus with the large participation of diverse groups and self-convened protesters, without any dominant ideological appeal or leader affiliation. In this article, I will analyze the ways in which these patterns of contra- dictory interactions formed, evaluated, or triggered various types of social relationships, by critically examining the content of viral images, memes, and widely shared posts by Gezi protesters on social media. In the absence of internal cohesion or an ideological and organizational agenda, I argue that widely shared viral images, memes, and text messages provided the content to collaboratively construct and publicly frame the autonomous logic of the “Gezi spirit” by the Gezi protesters. I aim to analyze this new understanding of collective identity in autono- mous logic processed through social media as a being-with (mit-sein), rather than a fusion of the individual to an enigmatic we-ness in order to represent “I”. I claim that this autonomous collectivity is driven by fluidarity as a public experience of the self in relation to the other without intermediary apparatuses and hence can be conceptualized as having built a new sociality. 

The centrosome is the main microtubule (MT)-organizing centre of animal cells. It consists of two centrioles and a multi-layered proteinaceous structure that surrounds the centrioles, the so-called pericentriolar material. Centrosomes promote de novo assembly of MTs and thus play important roles in Golgi organization, cell polarity, cell motility and the organization of the mitotic spindle. To execute these functions, centrosomes have to adopt particular cellular positions. Actin and MT networks and the association of the centrosomes to the nuclear envelope define the correct positioning of the centrosomes. Another important feature of centrosomes is the centrosomal linker that connects the two centrosomes. The centrosome linker assembles in late mitosis/G1 simultaneously with centriole disengagement and is dissolved before or at the beginning of mitosis. Linker dissolution is important for mitotic spindle formation, and its cell cycle timing has profound influences on the execution of mitosis and proficiency of chromosome segregation. In this review, we will focus on the mechanisms of centrosome positioning and separation, and describe their functions and mechanisms in the light of recent findings.

Chromosome loss that results in monosomy is detrimental to viability, yet it is frequently observed in cancers. How cancers survive with monosomy is unknown. Using p53-deficient monosomic cell lines, we find that chromosome loss impairs proliferation and genomic stability. Transcriptome and proteome analysis demonstrates reduced expression of genes encoded on the monosomes, which is partially compensated in some cases. Monosomy also induces global changes in gene expression. Pathway enrichment analysis reveals that genes involved in ribosome biogenesis and translation are downregulated in all monosomic cells analyzed. Consistently, monosomies display defects in protein synthesis and ribosome assembly. We further show that monosomies are incompatible with p53 expression, likely due to defects in ribosome biogenesis. Accordingly, impaired ribosome biogenesis and p53 inactivation are associated with monosomy in cancer. Our systematic study of monosomy in human cells explains why monosomy is so detrimental and reveals the importance of p53 for monosomy occurrence in cancer. The mechanisms that allow cancer cells to survive with monosomies are poorly understood. Here the authors analyse p53-deficient monosomic cell lines using transcriptomics and proteomics, and find that impaired ribosome biogenesis and p53 downregulation are associated with sustained monosomies.

This article examines the temporality of ephemeral visual posts to social media with an emphasis on Instagram stories. Drawing on theories of the spectacle, it is my contention that interaction and user-experience design, as it pertains to social media platforms, highlights the contemporary conditions and motivations in our society of abundant visual consumption. This article investigates what it means for a social media user to attend to such time-related visual experience. Throughout this piece, I critically survey the relationship between ephemeral Instagram stories’ popularity and the high speed temporality of the social media sphere with emphasis on the digital “picturesque.” Perishable daily sharing on social media reflects a contemplative glimpse into a personal lifespan presented as an object of mass appreciation. I examine how ephemerality as a component of design impacts online sociality through the picturesque visual mode. Contemporary boredom and competitive engagement in high-technological communication networks inform how we might direct digital publics to find alternative pathways to sociality.

Repair of double-stranded breaks generated by CRISPR/Cas9 is highly dependent on the flanking DNA sequence. To learn about interactions between DNA repair and target sequence, we measure frequencies of over 236,000 distinct Cas9-generated mutational outcomes at over 2800 synthetic target sequences in 18 DNA repair deficient mouse embryonic stem cells lines. We classify the outcomes in an unbiased way, finding a specialised role for Prkdc (DNA-PKcs protein) and Polm in creating 1 bp insertions matching the nucleotide on the protospacer-adjacent motif side of the break, a variable involvement of Nbn and Polq in the creation of different deletion outcomes, and uni-directional deletions dependent on both end-protection and end-resection. Using our dataset, we build predictive models of the mutagenic outcomes of Cas9 scission that outperform the current standards. This work improves our understanding of DNA repair gene function, and provides avenues for more precise modulation of Cas9-generated mutations. Here the authors measure how the absence of certain DNA repair genes change the frequencies of unique mutational outcomes generated by Cas9 DSBs at synthetic target sequences in mouse embryonic stem cells: they use this to build predictive models of the mutagenic outcomes of Cas9 scission.

Double-strand breaks (DSBs) are the most toxic type of DNA lesions. Cells repair these lesions using either end protection- or end resection-coupled mechanisms. To study DSB repair choice, we present the C olor A ssay T racing- R epair (CAT-R) to simultaneously quantify DSB repair via end protection and end resection pathways. CAT-R introduces DSBs using CRISPR/Cas9 in a tandem fluorescent reporter, whose repair distinguishes small insertions/deletions from large deletions. We demonstrate CAT-R applications in chemical and genetic screens. First, we evaluate 21 compounds currently in clinical trials which target the DNA damage response. Second, we examine how 417 factors involved in DNA damage response influence the choice between end protection and end resection. Finally, we show that impairing nucleotide excision repair favors error-free repair, providing an alternative way for improving CRISPR/Cas9-based knock-ins. CAT-R is a high-throughput, versatile assay to assess DSB repair choice, which facilitates comprehensive studies of DNA repair and drug efficiency testing. Cells employ different repair pathways to repair DNA double strand breaks. Here, the authors develop a CRISPR/Cas9-dependent method to study choices in DNA repair called the Color Assay Tracing-Repair (CAT-R) which simultaneously measure outcomes of DSB repair via end-protection and end-resection pathways.