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"Barber, Nicola"
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Cloning and genetic engineering
This enlightening volume offers arguments for both sides of the cloning and genetic engineering debate.
Book
Development and pilot testing of a three-dimensional, phenomenon-based unit that integrates evolution and heredity
To realize the promise of the Next Generation Science Standards, educators require new three-dimensional, phenomenon-based curriculum materials. We describe and report on pilot test results from such a resource—Evolution: DNA and the Unity of Life. Designed for the Next Generation Science Standards, this freely available unit was developed for introductory high school biology students. It builds coherent understanding of evolution over the course of seven to 8 weeks. Based around multiple phenomena, it includes core ideas about evolution, as well as pertinent core ideas from heredity. The unit integrates relevant crosscutting concepts as well as practice in analyzing and interpreting skill-level-appropriate data from published research, and constructing evidence-based arguments. We report results from a national pilot test involving 944 grade nine or ten students in 16 teachers’ classrooms. Results show statistically significant gains with large effect sizes from pretest to posttest in students’ conceptual understanding of evolution and genetics. Students also gained skill in identifying claims, evidence, and reasoning in scientific arguments.
Journal Article
Beyond the Central Dogma: Bringing Epigenetics into the Classroom
Epigenetics is the study of how external factors and internal cellular signals can lead to changes in the packaging and processing of DNA sequences, thereby altering the expression of genes and traits. Exploring the epigenome introduces students to environmental influences on our genes and the complexities of gene expression. A supplemental curriculum module developed by the Genetic Science Learning Center (GSLC) at the University of Utah brings epigenetics to high school and undergraduate classrooms through a range of online and paper-based activities. We describe these activities and provide strategies for incorporating both introductory and more advanced materials that explore “cell memory,” epigenetic inheritance, nutrition, and emerging connections between the epigenome and behavior. Finally, we outline recent reach on student learning gains using the GSLC's epigenetics module and provide connections to the Next Generation Science Standards.
Journal Article
Medieval medicine
Examines beliefs and practices, public health, and plague in the medieval world.
Book
Beyond the Central Dogma
Epigenetics is the study of how external factors and internal cellular signals can lead to changes in the packaging and processing of DNA sequences, thereby altering the expression of genes and traits. Exploring the epigenome introduces students to environmental influences on our genes and the complexities of gene expression. A supplemental curriculum module developed by the Genetic Science Learning Center (GSLC) at the University of Utah brings epigenetics to high school and undergraduate classrooms through a range of online and paper-based activities. We describe these activities and provide strategies for incorporating both introductory and more advanced materials that explore “cell memory,” epigenetic inheritance, nutrition, and emerging connections between the epigenome and behavior. Finally, we outline recent reach on student learning gains using the GSLC's epigenetics module and provide connections to the Next Generation Science Standards.
Journal Article
The death penalty
Explore one of the major global debates of our time, whether or not the death penalty is an abuse of human rights.
Book
Regulation of meiotic chromosome interactions in Caenorhabditis elegans
Faithful segregation of homologous chromosomes during meiosis requires pairing, synapsis, and crossing-over. In the nematode Caenorhabditis elegans, homolog pairing and synapsis depend on pairing centers, special regions near one end of each chromosome that interact with the nuclear envelope and cytoplasmic microtubules. Pairing centers are required for nuclear reorganization at the onset of meiosis. Here, I show that pairing centers recruit the Polo-like kinase PLK-2 to induce nuclear envelope remodeling, chromosome pairing, and synapsis. Recruitment of PLK-2 is also required to mediate a cell cycle delay and selective apoptosis of nuclei containing unsynapsed chromosomes, establishing a molecular link between these two quality control mechanisms. I also show that the checkpoint kinase CHK-2 is recruited to the interface of pairing centers and nuclear envelope proteins, consistent with its role in promoting homolog interactions and nuclear reorganization. Interestingly, PLK-2 is later recruited to the axes of paired and synapsed chromosomes where it plays a downstream role in synaptonemal complex dynamics. This work reveals new functions for the conserved family of Polo-like kinases, and advances our understanding of how meiotic processes are properly coordinated to ensure transmission of genetic information from parents to progeny.
Dissertation
Ancient Roman sports and pastimes
Learn about the many leisure activities enjoyed by the ancient Romans.
Book
The obscene beauty behind the fringe
A review of the fourth Barclay's New Stages Festival, displaying a range of fringe theatre performances.
Journal Article