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With successful treatment, the survival rate in Leukemia children is increasing, the effect of treatment related symptoms adverse on the health related quality of life is increasingly relevant. However, the etiology of these symptoms is unknown. The study aims to understand symptoms profile and potential biological correlates of children with leukemia during chemotherapy. This preliminary report is a part of an active IRB approved research protocol. Children age 5-21 diagnosed with Leukemia were recruited into the study. A Patient Reported Outcome Measurement Information System (PROMIS) questionnaire and blood sample were collected at before starting chemotherapy and second visit chemotherapy. Data was analyzed by SPSS version 22. Ten participants age 5-16 years old (6 boys and 4 girls) diagnosed with B cell Acute Lymphoblastic Leukemia (ALL) were included in this preliminary analysis. Participants were receiving chemotherapy in the maintenance and consolidation phase. PROMIS score showed participants experienced decreasing of anxiety and depression, increasing of fatigue and no change of pain severity from baseline to the second visit. Laboratory result showed a significant increase of creatinine, cholesterol, and triglyceride at the second visit (p <0.05). At the second visit, boys reported significant lower depression score (38.67 [+ or -] 2.4) than girls (46.35 [+ or -] 6.8) (p =0.03). This preliminary result open an interesting discussion on the potential involvement of lipid homeostasis in treatment related symptoms. This finding is a basis for future studies for an appropriate measurement of the children experiences and biological correlates of symptoms.

A bstract RADES (Relic Axion Detector Exploratory Setup) is a project with the goal of directly searching for axion dark matter above the 30 μ eV scale employing custom-made microwave filters in magnetic dipole fields. Currently RADES is taking data at the LHC dipole of the CAST experiment. In the long term, the RADES cavities are envisioned to take data in the BabyIAXO magnet. In this article we report on the modelling, building and characterisation of an optimised microwave-filter design with alternating irises that exploits maximal coupling to axions while being scalable in length without suffering from mode-mixing. We develop the mathematical formalism and theoretical study which justifies the performance of the chosen design. We also point towards the applicability of this formalism to optimise the MADMAX dielectric haloscopes.

A bstract We describe the results of a haloscope axion search performed with an 11.7 T dipole magnet at CERN. The search used a custom-made radio-frequency cavity coated with high-temperature superconducting tape. A set of 27 h of data at a resonant frequency of around 8.84 GHz was analysed. In the range of axion mass 36.5676 μ eV to 36.5699 μ eV, corresponding to a width of 554 kHz, no signal excess hinting at an axion-like particle was found. Correspondingly, in this mass range, a limit on the axion to photon coupling-strength was set in the range between g aγ ≳ 6.3 × 10 −13 GeV −1 and g aγ ≳ 1.59 × 10 −13 GeV −1 with a 95% confidence level.

A bstract We present results of the Relic Axion Dark-Matter Exploratory Setup (RADES), a detector which is part of the CERN Axion Solar Telescope (CAST), searching for axion dark matter in the 34.67 μ eV mass range. A radio frequency cavity consisting of 5 sub-cavities coupled by inductive irises took physics data inside the CAST dipole magnet for the first time using this filter-like haloscope geometry. An exclusion limit with a 95% credibility level on the axion-photon coupling constant of g aγ ≳ 4 × 10 − 13 GeV − 1 over a mass range of 34 . 6738 μ eV < m a < 34 . 6771 μ eV is set. This constitutes a significant improvement over the current strongest limit set by CAST at this mass and is at the same time one of the most sensitive direct searches for an axion dark matter candidate above the mass of 25 μ eV. The results also demonstrate the feasibility of exploring a wider mass range around the value probed by CAST-RADES in this work using similar coherent resonant cavities.