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The author in this qualitative, phenomenological research investigation explored parental perceptions of the benefits of using individualized autism parent training to help children with autism achieve higher levels of independence in self-care, toileting, and behavior skills. This study included six parents of children with autism as participants. The results of this study illustrate that the participants perceived individualized parent training interventions as focused, intentional, person-centered training methods designed to equip parents with individualized interventions provided by more knowledgeable individuals such as therapists to increase independence in the areas of self-care, toileting, and behavior skills. Moreover, the results of this study show that providing parental support using focused, intentional, person-centered methods of training can be effective in increasing parental confidence, as well as in building commitment to implement quality and supporting strategies opening doors to improving the adaptive, the behavioral, the emotional, and the overall quality of life for persons with autism.

[...]this report introduces Not One More Life (nOML), a health and faith partnership between volunteer medical providers and members and staff of churches serving primarily African American neighborhoods in Atlanta, Georgia. [...]NOML programs were held in a trusted setting of neighborhood churches with support of the church leadership. [...]strong local leadership was required for NOML programs to be sustained. [...]a fundamental tenet of the NOML mission was to support and equip the lay and professional health ministers within individual churches.

Background Inhaled nitric oxide (INO), a selective pulmonary vasodilator, has revolutionized the treatment of neonatal hypoxemic respiratory failure (NHRF). However, there is lack of sustained improvement in 30 to 46% of infants. Aerosolized prostaglandins I 2 (PGI 2 ) and E 1 (PGE 1 ) have been reported to be effective selective pulmonary vasodilators. The objective of this study was to evaluate the feasibility of a randomized controlled trial (RCT) of inhaled PGE 1 (IPGE 1 ) in NHRF. Methods Two pilot multicenter phase II RCTs are included in this report. In the first pilot, late preterm and term neonates with NHRF, who had an oxygenation index (OI) of ≥15 and <25 on two arterial blood gases and had not previously received INO, were randomly assigned to receive two doses of IPGE 1 (300 and 150 ng/kg/min) or placebo. The primary outcome was the enrollment of 50 infants in six to nine months at 10 sites. The first pilot was halted after four months for failure to enroll a single infant. The most common cause for non-enrollment was prior initiation of INO. In a re-designed second pilot, co-administration of IPGE 1 and INO was permitted. Infants with suboptimal response to INO received either aerosolized saline or IPGE 1 at a low (150 ng/kg/min) or high dose (300 ng/kg/min) for a maximum duration of 72 hours. The primary outcome was the recruitment of an adequate number of patients (n = 50) in a nine-month-period, with fewer than 20% protocol violations. Results No infants were enrolled in the first pilot. Seven patients were enrolled in the second pilot; three in the control, two in the low-dose IPGE 1 , and two in the high-dose IPGE 1 groups. The study was halted for recruitment futility after approximately six months as enrollment targets were not met. No serious adverse events, one minor protocol deviation and one pharmacy protocol violation were reported. Conclusions These two pilot RCTs failed to recruit adequate eligible newborns with NHRF. Complex management RCTs of novel therapies for persistent pulmonary hypertension of the newborn (PPHN) may require novel study designs and a longer period of time from study approval to commencement of enrollment. Trial registration: ClinicalTrials.gov Pilot one: NCT number: 00598429 registered on 10 January 2008. Last updated: 3 February 2011. Pilot two: NCT number: 01467076 17 October 2011. Last updated: 13 February 2013.