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"Beaty, Dave"
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Flashpoint : the world of Flashpoint featuring Wonder Woman
\"Flashpoint has changed the DC Universe, and nothing is as it was before. Now, a wedding between Wonder Woman-- Diana of the Amazons-- and Aquaman of Atlantis has turned deadly. Rocked by murder and betrayal, the two mythical warrior races take up arms-- and the rest of the world will pay the price. As Wonder Woman and the Amazons destrop their home of Themyscira and claim Great Britain as their new island nation, Aquaman and his Atlanteans will sacrifice millions of lives in an attempt to destroy their enemies\" -- p. [4] of cover.
Book
Management theory-building trends in South Africa : an archival analysis
A number of distinguished scholars believe that for theory development to occur within a field, qualitative research must precede empirical / quantitative research in order for the field to progress toward maturity. This study investigated the management literature published in South African journals from 1994-2004 to ascertain levels of use of qualitative, quantitative, conceptual and joint (quantitative and qualitative) research approaches in the field in South Africa. Conclusions on the trends of theory building in South Africa based on the research methodologies utilised in the extant literature are provided.
Journal Article
Advancing Ultraviolet Detector Technology for future missions: Investigating the dark current plateau in silicon detectors using photon-counting EMCCDs
Understanding the noise characteristics of high quantum efficiency silicon-based ultraviolet detectors, developed by the Microdevices Lab at the Jet Propulsion Laboratory, is critical for current and proposed UV missions using these devices. In this paper, we provide an overview of our detector noise characterization test bench that uses delta-doped, photon counting, Electron-multiplying CCDs (EMCCDs) to understand the fundamental noise properties relevant to all silicon CCDs and CMOS arrays. This work attempts to identify the source of the dark current plateau that has been previously measured with photon-counting EMCCDs and is known to be prevalent in other silicon-based arrays. It is suspected that the plateau could be due to a combination of detectable photons in the tail of blackbody radiation of the ambient instrument, low-level light leaks, and a non-temperature-dependent component that varies with substrate voltage. Our innovative test setup delineates the effect of the ambient environment during dark measurements by independently controlling the temperature of the detector and surrounding environment. We present the design of the test setup and preliminary results.
Paper
Max Bell court fight postponed
Lawyer Brian O'Leary, acting for the Alberta Treasury Branches, told court that lawyers for Larry Ryckman's company had requested a delay. O'Leary had been expected to seek an uncontested takeover of the company on behalf of the court-appointed receiver. A bankruptcy source said Wednesday that once the takeover was completed, the receiver, Coopers & Lybrand Ltd., would decide whether Ryckman's services would be required. Ryckman wants to continue working out of his arena offices and operating under a society he set up that holds the city arena's lease.
Newspaper Article
Hartman promise puzzles AADAC
\"I was rather amazed by those comments,\" said AADAC spokesman Brad Zipursky of [Don Hartman]'s pledge, made during his mayoralty campaign kickoff Thursday. Hartman said Friday, however, he knew about the planned AADAC facility but it was small and offers only out-patient services. Ald. Al Duerr, one of Hartman's main opponents in the election, called a press conference Friday to criticize Hartman's plans for a \"first of its kind\" treatment centre.
Newspaper Article
Genetics of Sputum Gene Expression in Chronic Obstructive Pulmonary Disease
Previous expression quantitative trait loci (eQTL) studies have performed genetic association studies for gene expression, but most of these studies examined lymphoblastoid cell lines from non-diseased individuals. We examined the genetics of gene expression in a relevant disease tissue from chronic obstructive pulmonary disease (COPD) patients to identify functional effects of known susceptibility genes and to find novel disease genes. By combining gene expression profiling on induced sputum samples from 131 COPD cases from the ECLIPSE Study with genomewide single nucleotide polymorphism (SNP) data, we found 4315 significant cis-eQTL SNP-probe set associations (3309 unique SNPs). The 3309 SNPs were tested for association with COPD in a genomewide association study (GWAS) dataset, which included 2940 COPD cases and 1380 controls. Adjusting for 3309 tests (p<1.5e-5), the two SNPs which were significantly associated with COPD were located in two separate genes in a known COPD locus on chromosome 15: CHRNA5 and IREB2. Detailed analysis of chromosome 15 demonstrated additional eQTLs for IREB2 mapping to that gene. eQTL SNPs for CHRNA5 mapped to multiple linkage disequilibrium (LD) bins. The eQTLs for IREB2 and CHRNA5 were not in LD. Seventy-four additional eQTL SNPs were associated with COPD at p<0.01. These were genotyped in two COPD populations, finding replicated associations with a SNP in PSORS1C1, in the HLA-C region on chromosome 6. Integrative analysis of GWAS and gene expression data from relevant tissue from diseased subjects has located potential functional variants in two known COPD genes and has identified a novel COPD susceptibility locus.
Journal Article
Utah KIDS must change methods
The Utah affiliate of a controversial adolescent drug treatment program coming to Calgary has been given three months to change its operations or have its licence revoked. Two Calgary aldermen said Thursday their support for the Calgary proposal hasn't wavered despite the controversies. Sharon Fisk and Carol Kraychy said they were aware of the criticisms before efforts began to bring the U.S.-based program to Calgary.
Newspaper Article
Flookes to take Shrake to court
[Bill Flookes] said the petition, with Shrake named as respondent, will cite the Contraverted Elections section of the Election Act. Flookes said he has sufficient evidence for a case and hopes a court battle will put the public spotlight on existing election procedures in a way not possible through a quiet government investigation. Even before the polls closed Monday, allegations started circulating about Shrake's efforts to get out the vote in his constituency. Opponents have charged that the Shrake campaign bused Chinese senior citizens to a polling station and issued facsimile ballots with an X by his name and Flookes' name misspelled. Flookes meanwhile, said the Fair Election Committee, chaired by Calgary writer Joanne Hendenstrom, will continue to monitor and compile allegations and rumors about the Shrake campaign.
Newspaper Article
Three killed in 22X crash
The incident has reopened the long-standing debate about the road's design and safety. It is a busy two lanes east of Macleod Trail and four lanes divided west of Macleod Trail. The city has posted large \"do not enter wrong way\" signs at intersections on Highway 22X west of Macleod Trail, including 6th, 14th, 24th, 37th and 53rd Streets, said Doug Bowron, the city's senior traffic engineer. At 14th Street South, for example, the two sets of Highway 22X lanes are separated by 91 metres. A driver not familiar with the area and heading south on 14th Street, then turning east onto Highway 22X could turn into the first road, the westbound lanes, developers and city officials said.
Newspaper Article
Identification of super-infected Aedes triseriatus mosquitoes collected as eggs from the field and partial characterization of the infecting La Crosse viruses
Background
La Crosse virus (LACV) is a pathogenic arbovirus that is transovarially transmitted by
Aedes triseriatus
mosquitoes and overwinters in diapausing eggs. However, previous models predicted transovarial transmission (TOT) to be insufficient to maintain LACV in nature.
Results
To investigate this issue, we reared mosquitoes from field-collected eggs and assayed adults individually for LACV antigen, viral RNA by RT-PCR, and infectious virus. The mosquitoes had three distinct infection phenotypes: 1) super infected (SI+) mosquitoes contained infectious virus, large accumulations of viral antigen and RNA and comprised 17 of 17,825 (0.09%) of assayed mosquitoes, 2) infected mosquitoes (I+) contained no detectable infectious virus, lesser amounts of viral antigen and RNA, and comprised 3.7% of mosquitoes, and 3) non-infected mosquitoes (I-) contained no detectable viral antigen, RNA, or infectious virus and comprised 96.21% of mosquitoes. SI+ mosquitoes were recovered in consecutive years at one field site, suggesting that lineages of TOT stably-infected and geographically isolated
Ae. triseriatus
exist in nature. Analyses of LACV genomes showed that SI+ isolates are not monophyletic nor phylogenetically distinct and that synonymous substitution rates exceed replacement rates in all genes and isolates. Analysis of singleton versus shared mutations (Fu and Li's F*) revealed that the SI+ LACV M segment, with a large and significant excess of intermediate-frequency alleles, evolves through disruptive selection that maintains SI+ alleles at higher frequencies than the average mutation rate. A QTN in the LACV NSm gene was detected in SI+ mosquitoes, but not in I+ mosquitoes. Four amino acid changes were detected in the LACV NSm gene from SI+ but not I+ mosquitoes from one site, and may condition vector super infection.
In contrast to NSm
, the NSs sequences of LACV from SI+ and I+ mosquitoes were identical.
Conclusions
SI+ mosquitoes may represent stabilized infections of
Ae. triseriatus
mosquitoes, which could maintain LACV in nature. A gene-for-gene interaction involving the viral NSm gene and a vector innate immune response gene may condition stabilized infection.
Journal Article