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A year for you : release the clutter, reduce the stress, recaim your life
\"Despite an innate desire to live peaceful and happy lives, many of us spend too much time in struggle and stress rather than enjoyment, often working to make others happy while forgetting about ourselves. In A Year for You, author and clutter clearing expert Stephanie Bennett Vogt explains The Spacious Way, a method that teaches you how to gently release the underlying causes of stress, struggle, and overwhelm. Through five practice areas; slowing down, simplifying, sensing, surrendering, and self care, this book is like a year long sabbatical to help you nourish your life and clear any physical, mental, emotional, or energetic clutter for good. The result is a quieter mind, a clearer home, and a more gentle, holistic understanding of the underlying causes of clutter and stress\"-- Provided by publisher.
Book
Quantifying gadolinium-based nanoparticle uptake distributions in brain metastases via magnetic resonance imaging
AGuIX, a novel gadolinium-based nanoparticle, has been deployed in a pioneering double-blinded Phase II clinical trial aiming to assess its efficacy in enhancing radiotherapy for tumor treatment. This paper moves towards this goal by analyzing AGuIX uptake patterns in 23 patients. A phantom was designed to establish the relationship between AGuIX concentration and longitudinal (
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) relaxation. A 3T MRI and MP2RAGE sequence were used to generate patient
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maps. AGuIX uptake in tumors was determined based on longitudinal relaxivity. AGuIX (or placebo) was administered to 23 patients intravenously at 100 mg/kg 1–5 hours pre-imaging. Each of 129 brain metastases across 23 patients were captured in
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maps and examined for AGuIX uptake and distribution. Inferred AGuIX recipients had average tumor uptakes between 0.012 and 0.17 mg/ml, with a mean of 0.055 mg/ml. Suspected placebo recipients appeared to have no appreciable uptake. Tumors presented with varying spatial AGuIX uptake distributions, suspected to be related to differences in accumulation time and patient-specific bioaccumulation factors. This research demonstrates AGuIX's ability to accumulate in brain metastases, with quantifiable uptake via
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mapping. Future analyses will extend these methods to complete clinical trial data (~ 134 patients) to evaluate the potential relationship between nanoparticle uptake and possible tumor response following radiotherapy.
Clinical Trial Registration Number:
NCT04899908.
Clinical Trial Registration Date:
25/05/2021.
Journal Article
Computerized Memory Training Leads to Sustained Improvement in Visuospatial Short-Term Memory Skills in Children with Down Syndrome
This study evaluated the impact of a computerized visuospatial memory training intervention on the memory and behavioral skills of children with Down syndrome. Teaching assistants were trained to support the delivery of a computerized intervention program to individual children over a 10–16 week period in school. Twenty-one children aged 7–12 years with Down syndrome were randomly allocated to either an intervention or waiting list control group. Following training, performance on trained and non-trained visuospatial short-term memory tasks was significantly enhanced for children in the intervention group. This improvement was sustained four months later. These results suggest that computerized visuospatial memory training in a school setting is both feasible and effective for children with Down syndrome.
Journal Article
From Silence to Strength: Challenging the Stigma of Familial Imprisonment
Children of prisoners (CoP) and their families experience stigmatisation simply because a family member is imprisoned. The stigma of familial imprisonment compels CoP to keep their family circumstances hidden, which intensifies isolation and restricts access to essential support. Furthermore, the impact of language used to represent CoP, along with media reporting of familial crimes, perpetuates stigmatising narratives and subsequent marginalisation. Despite long-standing recommendations, efforts to enhance provision for CoP in schools across England and Wales have been only partially implemented, resulting in inconsistent and inadequate support. As CoP remain unrecognised as a priority group, policy inaction and stigmatisation risk perpetuating cycles of exclusion. Drawing upon empirical data, this article provides a unique contribution to the academic field using a symbolic interactionist, labelling theory and critical realist framework to examine how targeted strength-based support for CoP can help them to reconstruct stigmatising narratives and mitigate negative outcomes by moving from a position of silence to a position of strength.
Journal Article
Three-Year Nursing PhD Model Recommendations from the RWJF Future of Nursing Scholars
Background:
In response to the 2011 Future of Nursing report, the Robert Wood Johnson Foundation created the Future of Nursing Scholars (FNS) Program in partnership with select schools of nursing to increase the number of PhD-prepared nurses using a 3-year curriculum.
Method:
A group of scholars and FNS administrative leaders reflect on lessons learned for stakeholders planning to pursue a 3-year PhD model using personal experiences and extant literature.
Results:
Several factors should be considered prior to engaging in a 3-year PhD timeline, including mentorship, data collection approaches, methodological choices, and the need to balance multiple personal and professional loyalties. Considerations, strategies, and recommendations are provided for schools of nursing, faculty, mentors, and students.
Conclusion:
The recommendations provided add to a growing body of knowledge that will create a foundation for understanding what factors constitute “success” for both PhD programs and students. [J Nurs Educ. 2022;61(1):19–28.]
Journal Article
Polycrystalline Formamidinium Lead Bromide X-ray Detectors
We have investigated the performance of formamidinium lead bromide (FAPbBr3) perovskite X-ray detectors fabricated from polycrystalline material that is pressed into a pellet at high pressures. FAPbBr3 has been shown to exhibit a remarkable combination of electrical and physical properties, such that mechanically-formed polycrystalline pellets exhibit good charge transport properties suitable for use as X-ray detectors. We characterise the morphology and structure of FAPbBr3 pellets using photoluminescence (PL), electron microscopy (SEM) and X-ray diffraction (XRD), and demonstrate an improvement in the microstructure, density, and charge transport performance of the material as the pressure is increased from 12 MPa to 124 MPa. The use of annealing of the pellets after pressing also improves the stability and charge transport performance of the devices. Using a 40 kV X-ray beam, a maximum X-ray sensitivity of 169 µC Gy−1 cm−2 was measured, and the fast time response of the devices was demonstrated using a chopped X-ray beam.
Journal Article
Macrophage interferon regulatory factor 4 deletion ameliorates aristolochic acid nephropathy via reduced migration and increased apoptosis
Aristolochic acid (AA) is the causative nephrotoxic alkaloid in AA nephropathy, which results in a tubulointerstitial fibrosis. AA causes direct proximal tubule damage as well as an influx of macrophages, although the role of macrophages in pathogenesis is poorly understood. Here, we demonstrate that AA directly stimulates migration, inflammation, and ROS production in macrophages ex vivo. Cells lacking interferon regulatory factor 4 (IRF4), a known regulator of macrophage migration and phenotype, had a reduced migratory response, though effects on ROS production and inflammation were preserved or increased relative to WT cells. Macrophage-specific IRF4-knockout mice were protected from both acute and chronic kidney effects of AA administration based on functional and histological analysis. Renal macrophages from kidneys of AA-treated macrophage-specific IRF4-knockout mice demonstrated increased apoptosis and ROS production compared with WT controls, indicating that AA directly polarizes macrophages to a promigratory and proinflammatory phenotype. However, knockout mice had reduced renal macrophage abundance following AA administration. While macrophages lacking IRF4 can adopt a proinflammatory phenotype upon AA exposure, their inability to migrate to the kidney and increased rates of apoptosis upon infiltration provide protection from AA in vivo. These results provide evidence of direct AA effects on macrophages in AA nephropathy and add to the growing body of evidence that supports a key role of IRF4 in modulating macrophage function in kidney injury.
Journal Article
Risk factors for mortality in septic patients who received etomidate
To characterize risk factors for mortality in septic patients who received etomidate for rapid sequence intubation.
This study was a retrospective cohort conducted at a large, tertiary, urban, academic medical center that included patients with severe sepsis or septic shock who received etomidate between January 1, 2010, and December 31, 2012.
A total of 169 patients were included with similar baseline characteristics. There were more men in the nonsurvivor group than in the survivor group (67.1% vs 50.6%, P = .03). Septic shock occurred in 91.5% of nonsurvivors and 69% of survivors (P < .01). Nonsurvivors also had a higher initial lactate of (5.1 ± 4.3 mmol/L vs 3.6 ± 3.4 mmol/L, P = .02) and more vasopressor therapy (91.5% vs 69%, P < .01), required a higher number of vasopressors (2.2 ± 1.1 vs 1.3 ± 1, P < .01), and were administered hydrocortisone (53.7% vs 34.5%, P = .01). Abdominal source of sepsis (P = .048) and number of vasopressors (P = .01) were predictive of 30-day mortality.
An alternative sedative induction agent may be considered for use in rapid sequence intubation in patients on multiple vasopressors or with abdominal source of infection.
Journal Article