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This multicentric randomized controlled trial (RCT), carried out in six Italian University mental health sites, aims to test the efficacy of a six-month psychosocial intervention (LYFESTYLE) on Body Mass Index (BMI), body weight, waist circumference, fasting glucose, triglycerides, cholesterol, Framingham and HOmeostasis Model Assessment of insulin resistance (HOMA-IR) indexes in patients with schizophrenia, bipolar disorder, and major depression. Moreover, the efficacy of the intervention has also been tested on several other physical and mental health domains. Patients were randomly allocated to receive the six-month experimental intervention (LIFESTYLE) or a behavioural control intervention. All enrolled patients were assessed at baseline and after one year. We recruited 401 patients (206 in the experimental and 195 in the control group) with a diagnosis of schizophrenia or other psychotic disorder (29.9%), bipolar disorder (43.3%), or major depression (26.9%). At one year, patients receiving the experimental intervention reported an improvement in body mass index, body weight, waist circumference, HOMA-IR index, anxiety and depressive symptoms and in quality of life. Our findings confirm the efficacy of the LIFESTYLE intervention in improving physical and mental health-related outcomes in patients with severe mental illnesses after one year.

This pathbreaking study links two traditionally separate genres as their stars crossed to explore the emergence of multiple selves in early modern Italian culture and society. Mauro Calcagno focuses on the works of Claudio Monteverdi, a master of both genres, to investigate how they reflect changing ideas about performance and role-playing by singers. Calcagno traces the roots of dialogic subjectivity to Petrarch's love poetry arguing that Petrarchism exerted a powerful influence not only on late Renaissance literature and art, but also on music. Covering more than a century of music and cultural history, the book demonstrates that the birth of opera relied on an important feature of the madrigalian tradition: the role of the composer as a narrative agent enabling performers to become characters and hold a specific point of view.

Abstract. In this study the resource base for EGS (enhanced geothermal systems) in Europe was quantified and economically constrained, applying a discounted cash-flow model to different techno-economic scenarios for future EGS in 2020, 2030, and 2050. Temperature is a critical parameter that controls the amount of thermal energy available in the subsurface. Therefore, the first step in assessing the European resource base for EGS is the construction of a subsurface temperature model of onshore Europe. Subsurface temperatures were computed to a depth of 10 km below ground level for a regular 3-D hexahedral grid with a horizontal resolution of 10 km and a vertical resolution of 250 m. Vertical conductive heat transport was considered as the main heat transfer mechanism. Surface temperature and basal heat flow were used as boundary conditions for the top and bottom of the model, respectively. If publicly available, the most recent and comprehensive regional temperature models, based on data from wells, were incorporated. With the modeled subsurface temperatures and future technical and economic scenarios, the technical potential and minimum levelized cost of energy (LCOE) were calculated for each grid cell of the temperature model. Calculations for a typical EGS scenario yield costs of EUR 215 MWh −1 in 2020, EUR 127 MWh −1 in 2030, and EUR 70 MWh −1 in 2050. Cutoff values of EUR 200 MWh −1 in 2020, EUR 150 MWh −1 in 2030, and EUR 100 MWh −1 in 2050 are imposed to the calculated LCOE values in each grid cell to limit the technical potential, resulting in an economic potential for Europe of 19 GW e in 2020, 22 GW e in 2030, and 522 GW e in 2050. The results of our approach do not only provide an indication of prospective areas for future EGS in Europe, but also show a more realistic cost determined and depth-dependent distribution of the technical potential by applying different well cost models for 2020, 2030, and 2050.

With the advent of fast imaging hardware and specialized software, additional non-invasive magnetic resonance characterization of tumors has become available through proton magnetic resonance spectroscopy (MRS), hemodynamic imaging and diffusion-weighted imaging (DWI). Thus, patterns could be discerned to discriminate different types of tumors and even to infer their possible evolution in time. The purpose of this study was to investigate the correlation between MRS, DWI, histopathology and Ki-67 labeling index in a large number of brain tumors. Localized proton spectra were obtained in 47 patients with brain tumors who subsequently underwent surgery (biopsy or tumor removal). We performed MRS with short echo-time (30 ms) and metabolic values in spectra were measured using an external software with 25 peaks. In all patients who had DWI, we measured apparent diffusion coefficients (ADC) in the same region of interest (ROI) where the voxel in MRS was located. In most tumors the histological diagnosis and Ki-67 labeling index had been determined on our original surgical specimen. Cho/Cr, (Lip+Mm)/Cr, NAA/(Cho+Cr) and Glx/Cr indexes in MRS allowed discriminating between low- and high-grade gliomas and metastases (MTs). Likewise, absolute ADC values differentiated low- from high-grade gliomas expressed by Ki-67 labeling index. A novel finding was that high Glx/Cr in vivo MRS index (similar to other known indexes) was a good predictor of tumor grading.

The aim of the last geothermal exploration campaign at the Lamentin lowland (Martinique) was to specify the characteristics and the extent of the local geothermal system. In this purpose, previous data were re-processed and new field data were acquired through geological, gravimetric, electromagnetic (CSEM and TEM) and fluids geochemical surveys. All the collected data were gathered in a 3D geological model leading to a new conceptual model. The Lamentin lowland is considered as an active graben controlled by major NW-SE faults and crossed by a NE-SW accommodating fault system. Recent, restricted and monogenic hydro-volcanism was highlighted, associated to large hydrothermal deposits from a first high temperature (HT) geothermal episode. Associated with thermal and soil gas anomalies and CO2-rich springs, they mark out the main faults. A shallow, thin and very conductive layer (<10 Qm) was mapped by CSEM and TEM, as the caprock of the previous HT geothermal system. Current geothermal fluid results from the mixing of 25-30% of seawater with fresh water flowing likely from the northern relief where annual precipitation exceeds 4 m. It is then heated to 115 ± 25°C and flows in a convective ascent through the major NW-SE fault. Northern Lamentin lowland appears to be a fault-limited and shallow medium enthalpy geothermal system.

People with severe mental illnesses (SMI) have a mortality rate two times higher compared to the general population, with a decade of years of life lost. In this randomized controlled trial (RCT), we assessed in a sample of people with bipolar disorder, major depressive disorder, and schizophrenia spectrum disorder, the efficacy of an innovative psychosocial group intervention compared to a brief psychoeducational group intervention on patients' body mass index (BMI), body weight, waist circumference, Framingham and HOMA-IR indexes. This is a multicentric RCT with blinded outcome assessments carried out in six Italian university centers. After recruitment patients were randomized to receive a 6-month psychosocial intervention to improve patients' physical health or a brief psychoeducational intervention. All recruited patients were assessed with standardized assessment instruments at baseline and after 6 months. Anthropometric parameters and blood samples have also been collected. Four-hundred and two patients with a diagnosis of bipolar disorder (43.3%), schizophrenia or other psychotic disorder (29.9%), or major depression (26.9%) were randomly allocated to the experimental (N = 206) or the control group (N = 195). After 6 months, patients from the experimental group reported a significant reduction in BMI (odds ratio [OR]: 1.93, 95% confidence intervals [CI]: 1.31-2.84; p < 0.001), body weight (OR = 4.78, 95% CI: 0.80-28.27, p < 0.05), and waist circumference (OR = 5.43, 95% CI: 1.45-20.30, p < 0.05). Participants with impaired cognitive and psychosocial functioning had a worse response to the intervention. The experimental group intervention was effective in improving the physical health in SMI patients. Further studies are needed to evaluate the feasibility of this intervention in real-world settings.

As part of the GEMex Project, an on-going European-Mexican effort to develop geothermal energy from non-conventional sources, preliminary geological models have been constructed for two sites located in the easternmost region of the Trans-Mexican Volcanic Belt. The first site, Los Humeros, which has produced geothermal electricity for decades, is investigated for its probable superhot geothermal resources. The second site, Acoculco, is a less known but promising area where application of an Enhanced Geothermal System is being studied. In order to have a coherent geological interpretation of both sites, preliminary 3-D models were constructed in a collaborative manner by European and Mexican partners. These models are based on data available at the start of the project, including geological maps, cross-sections and well logs. The data were mainly provided by the Comisión Federal de Electricidad (CFE), and the Mexican Centre for Innovation in Geothermal Energy (CeMIE-Geo consortium). A regional model was developed for each site and an additional local model was constructed for Los Humeros. The preliminary geological models serve as a framework for GEMex work on heat-transport and fluid-flow simulations; they will be updated and refined during the project, using new data and interpretations from ongoing and future field work on geology, geophysics, and geochemistry.

Introduction: Poor adherence to pharmacological treatment is frequent in people with severe mental disorders and it often causes lack of effectiveness of many psychotropic drugs. Thus, efforts should be made to improve adherence to pharmacological treatments in patients with these disorders. Methods: In this paper, based on the LIFESTYLE randomized, controlled multicentric trial, we aim to: 1) assess the level of adherence in a real-world sample of patients with severe mental disorders; 2) evaluate differences in treatment adherence according to patients’ socio-demographic and clinical characteristics; 3) evaluate the impact of an innovative psychosocial intervention, on patients’ adherence to treatments. The Lifestyle Psychosocial Group Intervention consists of group sessions, focused on different lifestyle behaviours, including healthy diet; physical activity; smoking habits; medication adherence; risky behaviours; and regular circadian rhythms. At end of each session a 20-min moderate physical activity is performed by the whole group. Results: The sample consists of 402 patients, mainly female (57.1%, N = 229), with a mean age of 45.6 years (±11.8). Less than 40% of patients reported a good adherence to pharmacological treatments. Adherence to treatments was not influenced by gender, age, diagnosis and duration of illness. At the end of the intervention, patients receiving the experimental intervention reported a significant improvement in the levels of adherence to treatments (T0: 35.8% vs. T3: 47.6%, p < 0.005). Patients practicing moderate physical activity reported a two-point improvement in the levels of adherence [odds ratio (OR): 1,542; 95% confidence intervals (CI): 1,157–2,055; p < 0.001], even after controlling for several confounding factors. Discussion: The experimental lifestyle intervention, which can be easily implemented in the routine clinical practice of mental health centres, was effective in improving adherence to pharmacological treatments.

Background Unhealthy eating patterns, physical inactivity and alcohol misuse are commonly reported by individuals with severe mental illness (SMI) and significantly contribute to premature mortality. People with SMI could benefit from psychoeducational interventions focused on lifestyle modification. Aims To evaluate the effectiveness of the LIFESTYLE programme to improve dietary habits and physical activity levels and reduce alcohol use in individuals with SMI versus controls receiving a less structured psychoeducational programme (Italian Ministry of University and Research, trial registration number: 2015C7374S). Method This multicentre randomised controlled trial (RCT) was conducted across six Italian universities and included 401 participants diagnosed with SMI, randomly allocated to either the test group or a comparison group. Results At 1-year follow-up, generalised estimating equations showed that the trial intervention boosted the likelihood of higher weekly metabolic equivalents of task (METs) expended on total activity (odds ratio 1.43, 95% CI 1.08–1.89; p < 0.01), on walking (odds ratio 1.50, 95% CI 1.18–1.90; p < 0.001) and on moderate activity (odds ratio 1.85, 95% CI 1.24–2.77; p < 0.01). Improvements in dietary habits included increased intake of fish (odds ratio 1.67, 95% CI 1.45–1.97; p < 0.05), fresh fruit (odds ratio 1.36, 95% CI 1.05–1.76; p < 0.05) and vegetables (odds ratio 1.91, 95% CI 1.56–1.96; p < 0.05), along with reduced junk food consumption (OR = 0.81, 95% CI 0.63–0.99; p < 0.05) and daily alcohol use (odds ratio 0.70, 95% CI 0.52–0.95; p < 0.05). Conclusions The LIFESTYLE intervention proved effective in promoting healthier lifestyles among individuals with SMI, with sustained benefits at 1 year. This structured programme could be a valuable addition to routine mental healthcare.