Journal Article

One-year efficacy of a lifestyle behavioural intervention on physical and mental health in people with severe mental disorders: results from a randomized controlled trial

Luciano, M., Siracusano, A., Fiorillo, A., Rossi, R., Rampino, A., Amore, M., Sampogna, G., Dell’Osso, L., Di Vincenzo, M., Carmassi, C., Rossi, A., D’Ambrosio, E., Calcagno, P., Bianciardi, E., Della Rocca, Bianca

2024

Overview

This multicentric randomized controlled trial (RCT), carried out in six Italian University mental health sites, aims to test the efficacy of a six-month psychosocial intervention (LYFESTYLE) on Body Mass Index (BMI), body weight, waist circumference, fasting glucose, triglycerides, cholesterol, Framingham and HOmeostasis Model Assessment of insulin resistance (HOMA-IR) indexes in patients with schizophrenia, bipolar disorder, and major depression. Moreover, the efficacy of the intervention has also been tested on several other physical and mental health domains. Patients were randomly allocated to receive the six-month experimental intervention (LIFESTYLE) or a behavioural control intervention. All enrolled patients were assessed at baseline and after one year. We recruited 401 patients (206 in the experimental and 195 in the control group) with a diagnosis of schizophrenia or other psychotic disorder (29.9%), bipolar disorder (43.3%), or major depression (26.9%). At one year, patients receiving the experimental intervention reported an improvement in body mass index, body weight, waist circumference, HOMA-IR index, anxiety and depressive symptoms and in quality of life. Our findings confirm the efficacy of the LIFESTYLE intervention in improving physical and mental health-related outcomes in patients with severe mental illnesses after one year.

• Publisher: Springer Berlin Heidelberg,Springer,Springer Nature B.V
• Subject: 2015C7374S / Adult / Analysis / Behavior Therapy - methods / Bipolar disorder / Bipolar Disorder - rehabilitation / Bipolar Disorder - therapy / Body Mass Index / Body weight / Cholesterol / Clinical trials / CRD / Depression, Mental / Depressive Disorder, Major - therapy / Female / Health aspects / Homeostasis / Humans / Insulin resistance / Insulin Resistance - physiology / Life Style / Lifestyles / Male / Medical advice systems / Medicine / Medicine & Public Health / Mental depression / Mental disorders / Mental health / Mentally ill / Middle Aged / Neurosciences / Original Paper / Outcome Assessment, Health Care / Patient compliance / Psychiatry / Psychosocial Intervention / Psychotic Disorders - physiopathology / Psychotic Disorders - therapy / Quality of Life / Schizophrenia / Schizophrenia - physiopathology / Schizophrenia - rehabilitation / Schizophrenia - therapy / Triglycerides / Waist Circumference - physiology