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Despite the increase in the research field of ethics in artificial intelligence, most efforts have focused on the debate about principles and guidelines for responsible AI, but not enough attention has been given to the “how” of applied ethics. This paper aims to advance the research exploring the gap between practice and principles in AI ethics by identifying how companies are applying those guidelines and principles in practice. Through a qualitative methodology based on 22 semi-structured interviews and two focus groups, the goal of the current study is to understand how companies approach ethical issues related to AI systems. A structured analysis of the transcripts brought out many actual practices and findings, which are presented around the following main research topics: ethics and principles, privacy, explainability, and fairness. The interviewees also raised issues of accountability and governance. Finally, some recommendations are suggested such as developing specific sector regulations, fostering a data-driven organisational culture, considering the algorithm’s complete life cycle, developing and using a specific code of ethics, and providing specific training on ethical issues. Despite some obvious limitations, such as the type and number of companies interviewed, this work identifies real examples and direct priorities to advance the research exploring the gap between practice and principles in AI ethics, with a specific focus on Spanish companies.

How predation events experienced by preys can shape phenotypic traits through the ontogenetic development of the interacting species should be a key issue in Evolutionary and Conservation Biology. Locomotor performance plays a fundamental role on the fitness of many animals, mainly because it enhances ability to fleeing from predators. Predators represent indeed a capital selective force on prey, mainly because they end prey life. However, predators may also damage prey by other means, such as injuries caused by failed attacks. This damage can severely affect locomotion, among several other aspects of prey fitness. In the case of anuran tadpoles, failed predator attacks often result in injured tails, which reduces swimming performance. However, little is known about lasting effects of those failed attacks on fleeing capabilities after metamorphosis. In this work, we clipped 55% tail length of pre‐tail‐resorption stage anaesthetized larval Pelobates cultripes toads, and compared metamorph hindlimb length and jump distance with metamorphs resulting from anaesthetized and non‐anaesthetized non‐clipped controls. Previous findings showed that this treatment produced metamorphs with reduced body condition. Results herein suggest that partial tail loss in tadpoles diminishes jumping performance of resultant metamorphs. This effect is likely a consequence of tail‐clipped tadpoles developing shorter hindlimbs as metamorphs, which is parallel to their reduced body condition. Therefore, predator attacks in the tail may be less potentially mortal than those in the head and body, but have costs in terms of an efficient antipredatory response that persist in post‐metamorphic stage. This effect might compromise metamorph ability to survive subsequent predator attacks. Resumen Cómo los episodios de depredación sufridos por las presas pueden modelar sus rasgos fenotípicos a través del desarrollo ontogénico de las especies que interactúan debería ser un tema central en Biología Evolutiva y de la Conservación. El desempeño locomotor representa un papel fundamental en la eficacia biológica de muchos animales, principalmente porque mejora la capacidad de eludir los ataques de los depredadores. Sin embargo, también pueden dañar a sus presas de otras maneras, como hiriéndolas a causa de ataques fallidos. En el caso de las larvas de anuros, los ataques fallidos de depredador a menudo lesionan la cola, lo cual reduce el desempeño locomotor. Sin embargo, se sabe poco sobre los posibles efectos de dichos ataques fallidos sobre la capacidad de huida después de la metamorfosis. En este trabajo, amputamos el 55% de la longitud de la cola de renacuajos anestesiados de Pelobates cultripes, justo antes de la reabsorción caudal, y comparamos la longitud de las extremidades posteriores de los metamórficos resultantes, así como la distancia de salto, con metamórficos provenientes de controles no amputados anestesiados y sin anestesiar. Estudios previos mostraron que este tratamiento produce metamórficos con menor índice de condición corporal. Nuestros resultados sugieren que la pérdida parcial de la cola en renacuajos disminuye el desempeño locomotor de los metamórficos resultantes. Este efecto es probablemente una consecuencia de la menor longitud de las extremidades posteriores en los metamórficos originados de larvas amputadas, lo que va en paralelo a su reducida condición corporal. Por tanto, los ataques de depredadores recibidos en la cola pueden ser menos mortíferos que aquellos causados en la cabeza y el cuerpo, pero tienen costes en términos de una respuesta antidepredatoria ineficiente que persisten en la fase posmetamórfica. Este efecto podría comprometer la capacidad de los metamórficos de sobrevivir a ataques subsecuentes de depredadores. A plain language summary is available for this article. Plain Language Summary

Amphibian populations are undergoing a major recession worldwide, likely triggered by global change components such as the global warming and pollutants, among which agrochemicals, in general, and fertilizers, in particular, play a central role given their relevance in agriculture. Potential synergies among these stressors could maximize their individual effects. In this work, we investigated the consequences of a controlled chronic exposure to increased temperature and a sublethal dose of ammonium during the larval stage of Pelophylax perezi frogs on the growth, development, and locomotor performance of tadpoles and the metamorphs they gave rise to. To that end, tadpoles were reared either in heated or nonheated tanks, with or without ammonium added. The parents of these tadpoles came from either a pine grove or an agrosystem. Survival was reduced in agrosystem tadpoles reared with ammonium. Increased temperature potentiated tadpole growth while giving way to smaller metamorphs. Faster growth could be a consequence of increased metabolism, whereas the smaller size could follow an accelerated development and metamorphosis, which reduced the growth period. Also, swimming speed was greater in tadpoles reared in heated tanks, while jumping distance was greater in metamorphs reared in nonheated tanks. The effects of temperature were more marked in agrosystem than in pine grove individuals, which could mirror reduced adaptability. Thus, the ability to withstand the effects of these stressors was lower in agrosystem tadpoles. When chronic exposure to ammonium and artificial heating were applied to tadpoles, tadpoles in heated water were larger, metamorphosed earlier, and as smaller metamorphs. Heated water produced faster larvae but metamorphs reared in nonheated water jumped farther. Ammonium caused increased mortality.

The emerging ecosystem of artificial intelligence (AI) ethics and governance auditing has grown rapidly in recent years in anticipation of impending regulatory efforts that encourage both internal and external auditing. Yet, there is limited understanding of this evolving landscape. We conduct an interview-based study of 34 individuals in the AI ethics auditing ecosystem across seven countries to examine the motivations, key auditing activities, and challenges associated with AI ethics auditing in the private sector. We find that AI ethics audits follow financial auditing stages, but tend to lack robust stakeholder involvement, measurement of success, and external reporting. Audits are hyper-focused on technically oriented AI ethics principles of bias, privacy, and explainability, to the exclusion of other principles and socio-technical approaches, reflecting a regulatory emphasis on technical risk management. Auditors face challenges, including competing demands across interdisciplinary functions, firm resource and staffing constraints, lack of technical and data infrastructure to enable auditing, and significant ambiguity in interpreting regulations and standards given limited (or absent) best practices and tractable regulatory guidance. Despite these roadblocks, AI ethics and governance auditors are playing a critical role in the early ecosystem: building auditing frameworks, interpreting regulations, curating practices, and sharing learnings with auditees, regulators, and other stakeholders.

Animal behaviour is under strong selection. Selection on behaviour, however, might not act in isolation from other fitness-related traits. Since predators represent outstanding selective forces, animal behaviour could covary with antipredator defences, such that individuals better suited against predators could afford facing the costs of riskier behaviours. Moreover, not all individuals undergo equivalent degrees of predation pressure, which can vary across sexes or habitats. Individuals under lower predation pressure might also exhibit riskier behaviours. In this work, I tested these hypotheses on natterjack toads ( ). Specifically, I gauged activity time, exploratory behaviour and boldness in standard laboratory conditions, and assessed whether they correlated with body size and antipredator strategies, namely sprint speed, parotoid gland area and parotoid gland colour contrast. Additionally, I compared these traits between sexes and individuals from an agrosystem and pine grove, since there is evidence that males and agrosystem individuals are subjected to greater predation pressure. Sprint speed as well as parotoid gland contrast and size appeared unrelated to the behavioural traits studied. In turn, body mass was negatively related to activity time, boldness and exploration. This trend is consistent with the fact that larger toads could be more detectable to their predators, which are mostly gape unconstrained and could easily consume them. As predicted, females exhibited riskier behaviours. Nonetheless, agrosystem toads did not differ from pine grove toads in the behavioural traits measured, despite being under stronger predation pressure.

Hepatocellular carcinoma (HCC) is a highly lethal liver cancer with late diagnosis; therefore, the identification of new early biomarkers could help reduce mortality. We determine the tissue and plasma status of five annexins during hepatocarcinogenesis by diethylnitrosamine-induced cirrhosis-HCC. We found that Anxa5 was the earliest upregulated gene at week 12 after HCC initiation, while Anxa1 and Anxa2 were upregulated in advanced HCC stages (weeks 18 and 22). Furthermore, the protein level of Annexin A1, A2, A5 and A10 was increased from the early stages. Immunofluorescence and subcellular fractionation revealed Annexin A1, A2, and A5 in the cytoplasm and nuclei of tumor cells. Notably, increased plasma levels of Annexin A5 significantly (r 2  = 0.8203) correlated with Annexin A5 levels in liver tissue from week 12 and gradually increased until week 22. Using the TCGA database, we found that the expression of ANXA2 (HR = 1.7, p  = 0.0046) and ANXA5 (HR = 1.8, p  = 0.00077) was associated with poor survival in HCC patients. In conclusion, we have identified Annexin A1 and A5 as potentially useful early biomarkers for poor prognosis in HCC patients.

In order to improve agriculture productivity, autonomous navigation algorithms are being developed so that robots can navigate along agricultural environments to automatize tasks that are currently performed by hand. This work uses machine vision techniques such as the Otsu’s method, blob detection, and pixel counting to detect the center of the row. Additionally, a commutable control is implemented to autonomously navigate a vineyard. Experimental trials were conducted in an actual vineyard to validate the algorithm. In these trials show that the algorithm can successfully guide the robot through the row without any collisions. This algorithm offers a computationally efficient solution for vineyard row navigation, employing a 2D camera and the Otsu’s thresholding technique to ensure collision-free operation.

Lung cancer has a very high mortality-to-incidence ratio, representing one of the main causes of cancer mortality worldwide. Therefore, new treatment strategies are urgently needed. Several diseases including lung cancer have been associated with the action of reactive oxygen species (ROS) from which hydrogen peroxide (H2O2) is one of the most studied. Despite the fact that H2O2 may have opposite effects on cell proliferation depending on the concentration and cell type, it triggers several antiproliferative responses. H2O2 produces both nuclear and mitochondrial DNA lesions, increases the expression of cell adhesion molecules, and increases p53 activity and other transcription factors orchestrating cancer cell death. In addition, H2O2 facilitates the endocytosis of oligonucleotides, affects membrane proteins, induces calcium release, and decreases cancer cell migration and invasion. Furthermore, the MAPK pathway and the expression of genes related to inflammation including interleukins, TNF-α, and NF-κB are also affected by H2O2. Herein, we will summarize the main effects of hydrogen peroxide on human lung cancer leading to suggesting it as a potential therapeutic tool to fight this disease. Because of the multimechanistic nature of this molecule, novel therapeutic approaches for lung cancer based on the use of H2O2 may help to decrease the mortality from this malignancy.

Oxidative stress results from a disturbed balance between oxidation and antioxidant systems. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) may be either harmful or beneficial to the cells. Ion channels are transmembrane proteins that participate in a large variety of cellular functions and have been implicated in the development of a variety of diseases. A significant amount of the available drugs in the market targets ion channels. These proteins have sulfhydryl groups of cysteine and methionine residues in their structure that can be targeted by ROS and RNS altering channel function including gating and conducting properties, as well as the corresponding signaling pathways associated. The regulation of ion channels by ROS has been suggested to be associated with some pathological conditions including liver diseases. This review focuses on understanding the role and the potential association of ion channels and oxidative stress in liver diseases including fibrosis, alcoholic liver disease, and cancer. The potential association between ion channels and oxidative stress conditions could be used to develop new treatments for major liver diseases.

Many ion channels are involved in tumor development, promoting cancer cell proliferation, migration, invasion, and survival. Accordingly, some of them have been suggested as tumor markers and novel targets for cancer therapy. Some sex steroid hormones (SSH), including estrogens and androgens, favor cancer progression. Meanwhile, other steroid hormones like vitamin D may have anticancer properties. SSH and vitamin D modulate the expression of a number of ion channels in cancer cells from hormone-sensitive tissues, including breast, ovary, prostate, and cervix. Moreover, rapid effects of SSH may be mediated by their direct action on membrane ion channels. Here, we reviewed the SSH and vitamin D regulation of ion channels involved in cancer, and analyzed the potential molecular pathways implicated. In addition, we described the potential clinical use of ion channels in cancer diagnosis and therapy, taking advantage of their regulation by SSH and vitamin D. Since SSH are considered risk factors for different types of cancer, and ion channels play important roles in tumor progression, the regulation of ion channels by SSH and vitamin D may represent a potential opportunity for early cancer diagnosis and therapeutic approaches in SSH and vitamin D sensitive tumors.