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BackgroundCurrent treatment options for knee osteoarthritis have limited effectiveness and potentially adverse side effects. Massage may offer a safe and effective complement to the management of knee osteoarthritis.ObjectiveExamine effects of whole-body massage on knee osteoarthritis, compared to active control (light-touch) and usual care.DesignMultisite RCT assessing the efficacy of massage compared to light-touch and usual care in adults with knee osteoarthritis, with assessments at baseline and weeks 8, 16, 24, 36, and 52. Subjects in massage or light-touch groups received eight weekly treatments, then were randomized to biweekly intervention or usual care to week 52. The original usual care group continued to week 24. Analysis was performed on an intention-to-treat basis.ParticipantsFive hundred fifty-one screened for eligibility, 222 adults with knee osteoarthritis enrolled, 200 completed 8-week assessments, and 175 completed 52-week assessments.InterventionSixty minutes of protocolized full-body massage or light-touch.Main MeasuresPrimary: Western Ontario and McMaster Universities Arthritis Index. Secondary: visual analog pain scale, PROMIS Pain Interference, knee range of motion, and timed 50-ft walk.Key ResultsAt 8 weeks, massage significantly improved WOMAC Global scores compared to light-touch (− 8.16, 95% CI = − 13.50 to − 2.81) and usual care (− 9.55, 95% CI = − 14.66 to − 4.45). Additionally, massage improved pain, stiffness, and physical function WOMAC subscale scores compared to light-touch (p < 0.001; p = 0.04; p = 0.02, respectively) and usual care (p < 0.001; p = 0.002; p = 0.002; respectively). At 52 weeks, the omnibus test of any group difference in the change in WOMAC Global from baseline to 52 weeks was not significant (p = 0.707, df = 3), indicating no significant difference in change across groups. Adverse events were minimal.ConclusionsEfficacy of symptom relief and safety of weekly massage make it an attractive short-term treatment option for knee osteoarthritis. Longer-term biweekly dose maintained improvement, but did not provide additional benefit beyond usual care post 8-week treatment.Trial Registrationclinicaltrials.gov NCT01537484

We present a genetic feedback control strategy enabling engineered microorganisms to self-regulate their population density. Our approach leverages a quorum sensing mechanism for the production of a growth inhibitor protein, whose activation is regulated by an embedded antithetic controller. Through mathematical modeling and steady-state analysis, we provide design guidelines to tune the control parameters. Finally, we validate the control architecture performance and robustness via realistic agent-based simulations in BSim. The proposed control architecture guarantees robust regulation of the cell density while relying on fewer constraints on the biological parameters with respect to other solutions presented in the literature.

Metabolic burden is a critical limiting factor in the design of synthetic circuits, affecting both their reliability and performance. To mitigate its effects, distributing control functions across different cell populations within a multicellular control architecture offers a promising solution, while simultaneously enhancing modularity and re-usability of the circuits. We first present a model that explicitly accounts for limited ribosome availability within cells. Using this framework, we then derive a mathematical model of a multicellular antithetic integral controller that incorporates these shared resources. Through numerical bifurcation analysis and in silico agent-based experiments in BSim, we compare the multicellular controller against its traditional single-cell (embedded) implementation, evaluating both resource utilization and stability.Competing Interest StatementThe authors have declared no competing interest.

Bursts of anger Your odds of having a heart attack increase nearly five-fold in the two hours after an angry outburst, found a study in the European Heart Journal, When you lose your cool, your blood pressure and heart rate shoot up and your blood vessels stiffen, which encourages clots to form.

Every day, eat at least one serving of probiotic-rich options such as yogurt, fermented veggies (like pickles or kimchi), or kombucha tea. 2 Eat more greens a mostly plant-based, whole-food diet will minimize inflammation At the same time, it doesn't hurt to bump up your protection with anti-inflammatory superstars like vitamin E (up to 1,200 IU daily) and quercetin (1.500 to 1.800 mg daily).

Their omega-3 fatty acids keep your entire cardiovascular system running smoothly- they've been proven to lower blood pressure, reduce the risk of blood clots, and prevent heart attacks.

The simplest way to fight cardiovascular disease: Bolster your body's bacteria

[...]when Johns Hopkins School of Medicine researchers tracked 1,055 medical students for 36 years, they found that those who were frequently angry experienced a sixfold increase in heart attacks.