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Le traumatisme est un concept pluriel qui se conjugue au rythme de ses origines et qui épouse les variations des tableaux cliniques qu’il entraîne. Lorsqu’il est précoce, nous parlons de trauma. Ce dernier affecte le narcissisme infantile, soit sur le plan identitaire, soit sur le plan identificatoire. La conception winnicottienne du traumatisme, selon laquelle ce dernier est le résultat de « l’échec » d’une relation de dépendance, s’articule parfaitement avec notre étude de cas. En effet, il s’agit de la clinique des fonctions maternelles primaires et plus particulièrement de la clinique de l’ object-presenting . L’hypothèse est que l’échec de la relation de dépendance entraîne l’échec de la fonction de l’ object-presenting autour de laquelle va se construire le dispositif thérapeutique. Ce dispositif doit offrir l’illusion de l’omnipotence afin que l’enfant devienne un sujet actif, désirant et créatif.

Le traumatisme est un concept pluriel qui se conjugue au rythme de ses origines et qui épouse les variations des tableaux cliniques qu’il entraîne. Lorsqu’il est précoce, nous parlons de trauma. Ce dernier affecte le narcissisme infantile, soit sur le plan identitaire, soit sur le plan identificatoire. La conception winnicottienne du traumatisme, selon laquelle ce dernier est le résultat de « l’échec » d’une relation de dépendance, s’articule parfaitement avec notre étude de cas. En effet, il s’agit de la clinique des fonctions maternelles primaires et plus particulièrement de la clinique de l’ object-presenting . L’hypothèse est que l’échec de la relation de dépendance entraîne l’échec de la fonction de l’ object-presenting autour de laquelle va se construire le dispositif thérapeutique. Ce dispositif doit offrir l’illusion de l’omnipotence afin que l’enfant devienne un sujet actif, désirant et créatif. Trauma is a plural concept which varies according to its origins and the various clinical presentations it can cause. When it takes place early, we talk about trauma. The latter affects infantile narcissism, either on the identity level or on the identificatory level. The Winnicottian concept of trauma, according to which trauma is the result of the “failure” of a relationship of dependency, links perfectly with our case study. Indeed, it is the clinic of primary maternal functions and particularly the clinic of “object-presenting.” The hypothesis suggests that the failure of the relationship of dependency leads to the failure of the “object-presenting” function around which the therapeutic system will be built. This system must offer the illusion of omnipotence so that the child becomes an active, desiring, and creative subject.

Background Abortion is a serious problem for sheep flocks and it is responsible for considerable economic losses. The epidemiological situation of abortion causing agents in sheep is poorly documented in Tunisia. This study aims to investigate the status of three abortion causing agents ( Brucella spp, Toxoplasma gondii, and Coxiella burnetii ) among organized flocks in Tunisia. Results A total of 793 sample blood collected from twenty-six flocks in seven governorates in Tunisia, were tested by indirect enzyme-linked immunosorbent assay (i-ELISA) for antibodies against three abortion causing agents ( Brucella spp , Toxoplasma   gondii, and Coxiella burnetii). Risk factors for individual-level seroprevalence were analyzed using a logistic regression model. Results revealed that 19.7%, 17.2%, and 16.1% of the tested sera were positive for toxoplasmosis, Q fever, and brucellosis, respectively. Mixed infection was found in all the flocks with 3 to 5 responsible abortive agents simultaneously. Logistic regression showed that the management practices (control of new introduction, common grazing and watering point, workers exchange, presence of lambing box on the farm) and the history of infertility and the presence of abortion in neighboring flocks were likely to increase the probability of being infected by the three abortive agents. Conclusions Evidence of the positive relationship between seroprevalence of abortion causing agents and several risk factors, suggests further investigations to better understand the etiology of infectious abortions in flocks to develop an applicable preventive and control program.

Background Key discoveries and innovations in the field of human genetics have led to the foundation of molecular and personalized medicine. Here, we present the Genome Tunisia Project, a two-phased initiative (2022–2035) which aims to deliver the reference sequence of the Tunisian Genome and to support the implementation of personalized medicine in Tunisia, a North African country that represents a central hub of population admixture and human migration between African, European, and Asian populations. The main goal of this initiative is to develop a healthcare system capable of incorporating omics data for use in routine medical practice, enabling medical doctors to better prevent, diagnose, and treat patients. Methods A multidisciplinary partnership involving Tunisian experts from different institutions has come to discern all requirements that would be of high priority to fulfill the project’s goals. One of the most urgent priorities is to determine the reference sequence of the Tunisian Genome. In addition, extensive situation analysis and revision of the education programs, community awareness, appropriate infrastructure including sequencing platforms and biobanking, as well as ethical and regulatory frameworks, have been undertaken towards building sufficient capacity to integrate personalized medicine into the Tunisian healthcare system. Results In the framework of this project, an ecosystem with all engaged stakeholders has been implemented including healthcare providers, clinicians, researchers, pharmacists, bioinformaticians, industry, policymakers, and advocacy groups. This initiative will also help to reinforce research and innovation capacities in the field of genomics and to strengthen discoverability in the health sector. Conclusions Genome Tunisia is the first initiative in North Africa that seeks to demonstrate the major impact that can be achieved by Human Genome Projects in low- and middle-income countries to strengthen research and to improve disease management and treatment outcomes, thereby reducing the social and economic burden on healthcare systems. Sharing this experience within the African scientific community is a chance to turn a major challenge into an opportunity for dissemination and outreach. Additional efforts are now being made to advance personalized medicine in patient care by educating consumers and providers, accelerating research and innovation, and supporting necessary changes in policy and regulation.