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Er is onvoldoende bekend over de middellangetermijnoverleving van niet-gemetastaseerd spierinvasieve blaaskanker (SIBC) na open (ORC) versus robotgeassisteerde (RARC) cystectomie, met of zonder neoadjuvante chemotherapie (NAC). Om de vijfjaarsoverleving na beide interventies en de invloed van NAC te onderzoeken, is een retrospectieve studie verricht in 19 Nederlandse ziekenhuizen tussen 2012 en 2015. Van de totaal 1.534 cT1-4N0-1-patiënten ondergingen 1.086 patiënten een ORC en 389 een RARC. De vijfjaarsoverleving was 51% na ORC (95%-BI 47–53) versus 58% na RARC (95%-BI 52–63); de hazard ratio na multivariabele correctie was 1,00 (95%-BI 0,84–1,20). 226 van de 965 cT2-4aN0-patiënten werden behandeld met NAC. Na case-control matching bleek (y)pT0 vaker voor te komen na NAC dan zonder NAC (31 vs. 15%; p  < 0,01). De beste vijfjaarsoverleving trad op bij patiënten met ypT0 na NAC, namelijk 89% (95%-BI 81–97). Concluderend laat deze deze studie bij patiënten met SIBC vergelijkbare vijfjaarsoverleving zien na ORC of na RARC. De beste overleving was bij patiënten die waren behandeld met NAC voorafgaand aan cystectomie. There is insufficient knowledge on intermediate-term survival of non-metastatic muscle-invasive bladder cancer (MIBC) after open (ORC) versus robot-assisted (RARC) cystectomy, with or without neo-adjuvant chemotherapy (NAC). This retrospective study was performed in 19 Dutch hospitals between 2012 and 2015 to assess the five-year survival after both interventions and the influence of NAC. Out of 1,534 cT1-4N0-1-patients, 1,086 patients were treated with ORC and 389 with RARC. The 5‑year survival rate after ORC was 51% (95% CI 47–53) versus 58% after RARC (95% CI 52–63), hazard ratio 1.00 (95% CI 0.84–1.20) after multivariable analysis. 226 of 965 cT2-4aN0 patients were treated with NAC. More patients had ypT0 after NAC than after no NAC (31% vs 15%; p  < 0.01). The best five-year survival was in patients with ypT0 after NAC (89%; 95% CI 81–97). This study shows similar five-year survival of MIBC patients treated with ORC or RARC and shows that the best survival was after NAC.

Samenvatting Er is onvoldoende bekend over de middellangetermijnoverleving van niet-gemetastaseerd spierinvasieve blaaskanker (SIBC) na open (ORC) versus robotgeassisteerde (RARC) cystectomie, met of zonder neoadjuvante chemotherapie (NAC). Om de vijfjaarsoverleving na beide interventies en de invloed van NAC te onderzoeken, is een retrospectieve studie verricht in 19 Nederlandse ziekenhuizen tussen 2012 en 2015. Van de totaal 1.534 cT1-4N0-1-patiënten ondergingen 1.086 patiënten een ORC en 389 een RARC. De vijfjaarsoverleving was 51% na ORC (95%-BI 47–53) versus 58% na RARC (95%-BI 52–63); de hazard ratio na multivariabele correctie was 1,00 (95%-BI 0,84–1,20). 226 van de 965 cT2-4aN0-patiënten werden behandeld met NAC. Na case-control matching bleek (y)pT0 vaker voor te komen na NAC dan zonder NAC (31 vs. 15%; p  < 0,01). De beste vijfjaarsoverleving trad op bij patiënten met ypT0 na NAC, namelijk 89% (95%-BI 81–97). Concluderend laat deze deze studie bij patiënten met SIBC vergelijkbare vijfjaarsoverleving zien na ORC of na RARC. De beste overleving was bij patiënten die waren behandeld met NAC voorafgaand aan cystectomie.

A high-resolution beam telescope is one of the most important and demanding infrastructure components at any test beam facility. Its main purpose is to provide reference particle tracks from the incoming test beam particles to the test beam users, which allows measurement of the performance of the device-under-test (DUT). \\LYCORIS, a six-plane compact beam telescope with an active area of \\(\\sim\\)10\\(\\times\\)\\SI{10}{\\square\\centi\\metre} (extensible to 10\\(\\times\\)\\SI{20}{\\square\\centi\\metre}) was installed at the \\DIITBF in 2019, to provide a precise momentum measurement in a \\SI{1}{\\tesla} solenoid magnet or to provide tracking over a large area. The overall design of \\LYCORIS will be described as well as the performance of the chosen silicon sensor. The \\SI{25}{\\micro\\metre} pitch micro-strip sensor used for \\LYCORIS was originally designed for the \\SID detector concept for the International Linear Collider. It adopts a second metallization layer to route signals from strips to the bump-bonded \\KPIX ASIC and uses a wire-bonded flex cable for the connection to the DAQ and the power supply system. This arrangement eliminates the need for a dedicated hybrid PCB. Its performance was tested for the first time in this project. The system has been evaluated at the \\DIITBF in several test-beam campaigns and has demonstrated an average single-point resolution of \\SI{7.07}{\\micro\\meter}.

We present a new concept for a multi-stage Zeeman decelerator that is optimized particularly for applications in molecular beam scattering experiments. The decelerator consists of a series of alternating hexapoles and solenoids, that effectively decouple the transverse focusing and longitudinal deceleration properties of the decelerator. It can be operated in a deceleration and acceleration mode, as well as in a hybrid mode that makes it possible to guide a particle beam through the decelerator at constant speed. The deceleration features phase stability, with a relatively large six-dimensional phase-space acceptance. The separated focusing and deceleration elements result in an unequal partitioning of this acceptance between the longitudinal and transverse directions. This is ideal in scattering experiments, which typically benefit from a large longitudinal acceptance combined with narrow transverse distributions. We demonstrate the successful experimental implementation of this concept using a Zeeman decelerator consisting of an array of 25 hexapoles and 24 solenoids. The performance of the decelerator in acceleration, deceleration and guiding modes is characterized using beams of metastable Helium (\\(^3S\\)) atoms. Up to 60 % of the kinetic energy was removed for He atoms that have an initial velocity of 520 m/s. The hexapoles consist of permanent magnets, whereas the solenoids are produced from a single hollow copper capillary through which cooling liquid is passed. The solenoid design allows for excellent thermal properties, and enables the use of readily available and cheap electronics components to pulse high currents through the solenoids. The Zeeman decelerator demonstrated here is mechanically easy to build, can be operated with cost-effective electronics, and can run at repetition rates up to 10 Hz

We demonstrate the successful experimental implementation of a multi-stage Zeeman decelerator utilizing the new concept described in the accompanying paper. The decelerator consists of an array of 25 hexapoles and 24 solenoids. The performance of the decelerator in acceleration, deceleration and guiding modes is characterized using beams of metastable Helium (\\(^3S\\)) atoms. Up to 60% of the kinetic energy was removed for He atoms that have an initial velocity of 520 m/s. The hexapoles consist of permanent magnets, whereas the solenoids are produced from a single hollow copper capillary through which cooling liquid is passed. The solenoid design allows for excellent thermal properties, and enables the use of readily available and cheap electronics components to pulse high currents through the solenoids. The Zeeman decelerator demonstrated here is mechanically easy to build, can be operated with cost-effective electronics, and can run at repetition rates up to 10 Hz.